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Dual RF, ACPA positivity linked to RA manifestations
03 Nov 2025
byStephen Padilla
Patients with rheumatoid arthritis (RA) who are positive for both anticyclic citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) have lower remission rate, higher baseline erythrocyte sedimentation rate (ESR), and need more corticosteroid and disease-modifying antirheumatic drugs (DMARDs) than those with single positivity or double negativity, according to a Singapore study.








