News & Updates

Starting dose of CDK4/6 inhibitors linked to survival in metastatic breast cancer

Progression-free (PFS) and overall survival (OS) are similar between age groups (≥70 and <70 years) among  patients treated with cyclin-dependent kinase (CDK) 4/6 inhibitors from 2015 to 2019, with no significant differences in neutropaenia or thrombocytopaenia toxicity, reports a study.

Screen time may affect brain development in early childhood

In preschool-aged children, higher digital media use (screen time) was associated with lower cortical thickness (CT) and sulcal depth (SD), according to a secondary analysis of data collated for an MRI-based study.

Torsemide, furosemide yield similar survival outcomes in heart failure

Treatment with torsemide in survivors of heart failure hospitalization appears to have a similar effect on all-cause mortality over 12 months as furosemide, according to data from the open-label TRANSFORM-HF study.

Obesity common among children with medical complexity

Children with medical complexity (CMC) are significantly more likely to be overweight or obese compared with children without chronic medical conditions, according to a recent study.

The role of oral antivirals in COVID-19 treatment: Who, when, and how?

Though most countries have eased pandemic restrictions, there is no room for complacency in managing COVID-19, which continues to cause significant morbidity and mortality.

At a recent symposium, esteemed experts Dr Roger Paredes, Head of Department of Infectious Diseases at the Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain, and Dr Nicola Petrosillo, Head of the Infection Prevention and Control and Infectious Disease Service at University Hospital Campus Bio-Medico, Rome, Italy, gave global perspectives on the continuing unmet needs in the COVID-19 outpatient landscape and discussed the role of antiviral treatment options in patients at risk of progressing to severe COVID-19. Dr Petrick Periyasamy, Head of Infectious Diseases Unit, Medical Department, UKM Medical Centre, Kuala Lumpur, Malaysia, chaired the session.

Switching from ARB, ACEI to sacubitril/valsartan ups angioedema risk

New users of sacubitril-valsartan (SV) show no increased risk of angioedema when compared to users of angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB), reports a study.

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

An earlier onset of fever appears to predict a more severe and progressive cytokine release syndrome, a life-threatening hyper-inflammatory state caused by immune effector cell therapy, suggests a study. Such condition also warrants several doses of anti-interleukin (IL)-6 therapy, such as tocilizumab.