News & Updates

Among untreated patients with compensated cirrhosis, episodic low-level viraemia (LLV) is not associated with a higher risk of disease progression relative to maintained virological response (MVR) status, reveals a recent study. Consequently, the benefits of antiviral therapy (AVT) for episodic LLV must be re-evaluated.

Implementation of educational interventions targeted at deprescribing proton pump inhibitors (PPIs) has led to a sustained decrease in PPI use for more than 12 months at the institution level, according to a Singapore study.

The eosinophilic esophagitis (EoE) histologic scoring system (HSS) displays high responsiveness and similar performance to peak eosinophil count (PEC), reports a study. In addition, EoE-HSS is more highly associated with changes in overall histologic activity.

Guselkumab, a selective p19 interleukin-23 antagonist, induces better 12-week clinical and endoscopic improvements relative to placebo without triggering alarming side effects, reports a new phase II trial.

Symptoms are not a good indicator of gluten exposure in either patients with coeliac disease (CD) or noncoeliac gluten sensitivity (NCGS), suggests a study. Production of serum interleukin (IL)-2 signals a rapid-onset gluten-induced T-cell activation in CD despite long-standing treatment.

A triplet chemotherapeutic (CT) regimen comprising docetaxel, cisplatin, and 5-fluororacil (5-FU; DCF) outdid a doublet regimen comprising CF as neoadjuvant treatment for locally advanced oesophageal squamous cell carcinoma (ESCC), the phase III JCOG*1109 NExT study suggests.