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Can indoleacetic acid help overcome P. vulgatus–induced IO resistance in HCC?
25 Nov 2025
byNatalia Reoutova
Researchers from the University of Hong Kong (HKU) have identified enrichment in Phocaeicola vulgatus as a potential cause for immunotherapy (IO) resistance in patients with hepatocellular carcinoma (HCC) and shown Sthat supplementation with indoleacetic acid (IAA) can overcome P. vulgatus–induced immunosuppression, thereby establishing a causal relationship between P. vulgatus and anti–PD-1 resistance in HCC.








