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Novel tenofovir formulation noninferior to disoproxil fumarate in chronic hepatitis B
In the treatment of patients with chronic hepatitis B (CHB), the novel tenofovir amibufenamide (TMF) is as good as tenofovir disoproxil fumarate (TDF) in terms of efficacy but with the advantage of better bone and renal safety, according to the results of a noninferiority trial.

Spike mutations in COVID-19 variants threaten vaccine efficacy
Due to mutations in the virus’ Spike protein, the antibody neutralization activity of convalescent patients with the coronavirus disease 2019 (COVID-19) seems to be attenuated against the B.1.1.7 and B.1.351 strains of SARS-CoV-2, according to a recent Singapore study.

Do mRNA COVID-19 vaccines influence treatment for rheumatic diseases?
In individuals receiving disease-modifying antirheumatic drugs* (DMARDs) for inflammatory rheumatic diseases** (IRD), humoral response remained satisfactory following administration of the second dose of the Pfizer mRNA vaccine against SARS-CoV-2, a study suggests.

Rapid test for COVID-19 not so perfect
Panbio, a rapid antigen test for SARS-CoV-2, has good specificity but limited sensitivity, as shown in a study. As such, all negative tests have to be confirmed with RT-PCR, especially in the presence of related symptoms, in settings with high community infection rate, and in cases of direct contact with confirmed COVID-19 patients.




