Diabetes mellitus is a growing health problem traditionally characterized by peripheral insulin resistance (IR), increased hepatic gluconeogenesis, and impaired pancreatic beta-cell function. However, the pathophysiology of T2DM is complex, and disease progression is linked to factors beyond insulin dysregulation and reduced first-phase insulin response.
02 Aug 2023
byJoanne G. Blanco, MD
Diabetes mellitus is a growing health problem traditionally characterized by peripheral insulin resistance (IR), increased hepatic gluconeogenesis, and impaired pancreatic beta-cell function.1 However, the pathophysiology of T2DM is complex, and disease progression is linked to factors beyond insulin dysregulation and reduced first-phase insulin response.2 Unfortunately, many existing anti-hyperglycemic medications cause side effects such as hypoglycemia and weight gain, which may reduce adherence to treatment. In contrast, ideal diabetes medications would control glycemia without a risk of hypoglycemia, while providing additional beneficial effects on beta-cell function, body weight, lipid profiles, hypertension and cardiovascular risk.3
Diabetes mellitus is a growing health problem traditionally characterized by peripheral insulin resistance (IR), increased hepatic gluconeogenesis, and impaired pancreatic beta-cell function. However, the pathophysiology of T2DM is complex, and disease progression is linked to factors beyond insulin dysregulation and reduced first-phase insulin response.
02 Aug 2023
