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2 drugs in 1 pill better than complex regimens for HIV
The combination of bictegravir and lenacapavir, taken orally once daily, performed better than current complex treatment regimens in the phase II ARTISTRY-1 trial of people with HIV who are virologically suppressed.
Growing incidence of HPV-positive oropharyngeal cancer in HK
A retrospective study by the Chinese University of Hong Kong (CUHK) reports a growing incidence of oropharyngeal cancer, with an increasing proportion of human papillomavirus (HPV)–positive cases in Hong Kong in recent years.
Novel drug significantly cuts triglyceride levels
The investigational RNAi therapeutic plozasiran significantly reduced triglyceride levels in individuals with severe hypertriglyceridaemia (SHTG) who were at high risk for pancreatitis, according to the final results of the phase IIb SHASTA-2 trial.
Open-access upper endoscopy fast-tracks diagnosis for nonalarming symptoms in SG
Open-access esophagogastroduodenoscopy (OAE) facilitates a safe and timely evaluation of patients with nonalarming digestive issues in Singapore, according to a study.
Add-on desloratadine helps reduce acne itching, improve treatment satisfaction
Adding desloratadine to an isotretinoin regimen appears to reduce pruritus in acne, leading to a higher patient satisfaction, as shown in a study.
Filgotinib for ulcerative colitis holds up in real world
The oral Janus kinase (JAK) 1 preferential inhibitor filgotinib appears to be safe and effective in the treatment of Asian patients with ulcerative colitis, according to real-world data.
Testosterone replacement therapy of little help in preventing diabetes in hypogonadal men
Testosterone replacement therapy in men with hypogonadism does not appear to reduce the risk of developing diabetes, according to the results of the TRAVERSE* substudy.
Meta-analysis: Abbreviated DAPT after PCI may be considered for older adults
Older adults who have undergone percutaneous coronary intervention (PCI) may do well with a shortened dual antiplatelet therapy (DAPT) duration, which has been shown to reduce the risk of bleeding without increasing the risk of adverse clinical events in a network meta-analysis.
Screen time interferes with creation of talk-rich environment for children
Increased screen time among children may be hurting their opportunities to talk and interact in their home environment, according to a study from Australia.
Benralizumab beneficial to Asians with severe eosinophilic asthma
The efficacy of benralizumab against severe eosinophilic asthma has been confirmed in an Asian population, with results consistent with the global data, as shown in the phase III MIRACLE trial.
