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Esketamine outperforms quetiapine in head-to-head depression trial
In patients with treatment-resistant depression, esketamine nasal spray appears to have superior efficacy compared with extended-release quetiapine when used in combination with conventional antidepressants.

Postpartum depression more common in pregnant women with rheumatic disease
Women of reproductive age with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), or rheumatoid arthritis (RA) are more likely to experience postpartum depression than those without any rheumatic disease (RD), according to a study.

Antipsychotic dose reduction in recurrent psychosis: No clear benefits but increased relapse risk
Gradual antipsychotic dose reduction does not provide benefits in social functioning and is associated with an increased risk of relapse in patients with schizophrenia, the RADAR trial has shown.

COVID vs non-COVID ARDS: Are both mentally distressing for patients’ kin?
Mental health symptoms of family members of patients hospitalized for acute respiratory distress syndrome (ARDS) were similar at 12 months regardless of whether it was caused by COVID-19 or not, a prospective cohort study suggests.

Pill pause linked to adverse mental health symptoms in long-term contraceptive users
For long-term users of combined oral contraceptives (COC), short-term hormonal withdrawal that occurs during the once-a-month pill pause appears to be accompanied by a significant increase in negative affect, anxiety, and mental health symptoms, regardless of COC type, as reported in a study.

Mindfulness therapy reduces IBS symptoms, improves life quality
Mindfulness-based stress reduction therapy (MBSRT) in patients with irritable bowel syndrome (IBS) results in improved quality of life and mindfulness components, as well as reduced IBS symptoms, when compared with controls, a study has shown.


