News & Updates

Knowledge and awareness of the gut microbiome are relatively low among the general population in Singapore, but practices of gut health modification are common, reports a study.

Rifasutenizol demonstrates efficacy in the treatment of Helicobacter pylori infection, according to the results of the phase III EVEREST-HP trial.

The use of antibiotics to treat paediatric appendicitis should target Escherichia coli and anaerobes, suggests a study. Two other bacteria are also present in about a fourth of the cultures, namely viridans group streptococci (VGS) and pseudomonas.

Routine screening for Helicobacter pylori infection in patients with acute myocardial infarction (MI) does not help lower the risk of upper gastrointestinal bleeding, according to a crossover trial.

In the treatment of hospitalized patients with COVID-19 pneumonia, the use of the neutralizing monoclonal antibody sotrovimab in addition to usual care reduces mortality but only in the subgroup of those with a high baseline serum SARS-CoV-2 antigen concentration, according to the open-label RECOVERY trial.

Switching to a doravirine-based ARV regimen resolves neuropsychiatric AEs that were ongoing during a prior efavirenz-based regimen in DRIVE-AHEAD, with few events persisting 96 weeks after switching — a finding also seen in DRIVE-FORWARD, as shown in post hoc analyses of the OLEs of the two phase III trials

The use of the antihistamine nasal spray azelastine may help prevent SARS-CoV-2 respiratory infections, as shown in a phase II study.