News &amp; Updates

Use of biologics provides clinical benefits in patients with chronic, refractory inflammatory conditions of the pouch, with no new safety signals observed, reports a study. Moreover, infliximab appears more effective than adalimumab and vedolizumab for chronic antibiotic-refractory pouchitis (CARP).

Biologics effective, safe for inflammatory conditions of the pouch

Coconut water beneficial in ulcerative colitis

Drinking coconut water may help individuals with mild-to-moderate ulcerative colitis achieve remission, as shown in a study.

Coconut water beneficial in ulcerative colitis

Plasma omega-3 PUFA not causally linked to sarcopenia-related traits

A two-sample Mendelian randomization (MR) study has found no causal effect of plasma omega-3 polyunsaturated fatty acids (PUFAs) on sarcopenia-related traits, such as lean mass, grip strength, and walking pace.

Plasma omega-3 PUFA not causally linked to sarcopenia-related traits

Avelumab with paclitaxel plus ramucirumab shows promise in esophagogastric adenocarcinoma

Combining the programmed cell death ligand 1 (PDL-1) inhibitor avelumab with paclitaxel plus ramucirumab appears to be efficacious and safe in the second-line treatment of metastatic esophagogastric adenocarcinoma, as shown in the phase II nonrandomized RAP trial.

Avelumab with paclitaxel plus ramucirumab shows promise in esophagogastric adenocarcinoma

Shortened terlipressin therapy after endoscopic haemostasis as effective as 3-day course

20 Jan 2024

In cirrhosis patients with acute variceal bleeding (AVB), treatment with terlipressin for a single day yields similar rebleeding and mortality rates as 3-day treatment following endoscopic haemostasis, while having an overall superior safety profile, according to a study.

Shortened terlipressin therapy after endoscopic haemostasis as effective as 3-day course

20 Jan 2024

Linaclotide improves bowel movement frequency in children with functional constipation

20 Jan 2024 by

Once-daily treatment with linaclotide, a guanylate cyclase C agonist, significantly improved the frequency of spontaneous bowel movements (SBMs) in paediatric patients with functional constipation, according to a recent study.

Linaclotide improves bowel movement frequency in children with functional constipation

20 Jan 2024

Probiotic Bif195 helps protect against aspirin-induced stomach damage

19 Jan 2024 by

The probiotic strain Bifidobacterium breve (Bif195), when co-administered with aspirin, appears to mitigate stomach injury caused by aspirin, according to the results of a randomized crossover trial.

Probiotic Bif195 helps protect against aspirin-induced stomach damage

TaTME-DCAA feasible for low rectal cancer

19 Jan 2024 by

A retrospective, propensity score-matched analysis from Singapore demonstrates the feasibility of transanal total mesorectal excision with delayed coloanal anastomosis (TaTME-DCAA) as a surgical alternative for non-metastatic low rectal cancer.

TaTME-DCAA feasible for low rectal cancer

Linaclotide works well for functional constipation in children

The guanylate cyclase C agonist linaclotide helps increase the frequency of bowel movements in children with functional constipation, according to data from a phase III trial.

Linaclotide works well for functional constipation in children