Oral sodium bicarbonate a feasible alternative for high-dose MTX urine alkalinization
Oral sodium bicarbonate with Lactated Ringer’s solution (LR) is a good option for urine alkalization to ease nephrotoxicity caused by high-dose methotrexate (MTX; doses ≥500 mg/m2), suggests a study. Moreover, the total dose of sodium bicarbonate used is lower in the oral than the intravenous (IV) cohort, with no additional delays in clearance.
