News &amp; Updates

Treatment with anticoagulants helps improve survival in patients with cirrhosis and portal vein thrombosis independently of recanalization, suggests a study. However, anticoagulation may increase the risk of nonportal hypertension-related bleeding.

Anticoagulation lowers mortality in patients with cirrhosis, portal vein thrombosis

‘Triple-G’ obesity drug also targets NAFLD in phase II trial

In a subanalysis of a phase II trial on obesity, retatrutide, a triagonist of GIP*, GLP**, and glucagon receptors, also demonstrated multiple favourable signals for nonalcoholic fatty liver disease (NAFLD).

‘Triple-G’ obesity drug also targets NAFLD in phase II trial

11 Jul 2023

Intralesional botulinum toxin proven safe, effective in nail psoriasis

A single injection of intralesional botulinum toxin (BTX) demonstrates long-term efficacy and is well tolerated in patients with nail psoriasis, according to a randomized intraindividual controlled study presented at the recent WCD 2023. BTX is also as effective as multiple intralesional steroid injections.

Intralesional botulinum toxin proven safe, effective in nail psoriasis

Palliative care for interstitial lung disease more difficult than for lung cancer

Providing palliative care (PC) for patients with interstitial lung disease (ILD) appears more challenging than for those with lung cancer (LC), according to a study. Pulmonary specialists have also cited some ILD-specific barriers in PC.

Palliative care for interstitial lung disease more difficult than for lung cancer

11 Jul 2023

Differential response to donepezil across MCI subtypes

A double-blind randomized controlled trial (RCT) finds that donepezil offers greater benefit in mild cognitive impairment (MCI) among individuals with hippocampal-sparing or minimal atrophy subtype vs individuals with typical or limbic-predominant patterns of atrophy.

Differential response to donepezil across MCI subtypes

KEYNOTE-826: Sustained survival benefit with pembro + chemo in advanced cervical cancer

The addition of pembrolizumab immunotherapy to chemotherapy, either with or without bevacizumab, continues to confer survival benefit in patients with persistent, recurrent, or metastatic cervical cancer, regardless of their programmed death-ligand 1 (PD-L1) combined positive score (CPS), according to the updated results of the KEYNOTE-826 trial presented at ASCO 2023.

KEYNOTE-826: Sustained survival benefit with pembro + chemo in advanced cervical cancer

Spesolimab curbs flares in generalized pustular psoriasis

10 Jul 2023 by

The anti-interleukin (IL)-36 receptor monoclonal antibody spesolimab not only helps treat generalized pustular psoriasis (GPP) flares but also prevent them, according to the results of the Effisayil 2 study presented at WCD 2023.

Spesolimab curbs flares in generalized pustular psoriasis

$Tocilizumab an effective substitute to anti-TNF agents in refractory Behçet disease$

Tocilizumab an effective substitute to anti-TNF agents in refractory Behçet disease

Tocilizumab (TCZ) may be used as an alternative treatment to antitumour necrosis factor (anti-TNF) agents for patients with Behçet disease (BD)-related uveitis and neurological manifestations, a recent study has shown.

Tocilizumab an effective substitute to anti-TNF agents in refractory Behçet disease

Does polypharmacy affect survival in older patients with haematological malignancy?

10 Jul 2023 by

Polypharmacy does not appear to result in poorer treatment response and survival in older patients with different haematological malignancies, as shown in a study presented at the recent EHA 2023.

Does polypharmacy affect survival in older patients with haematological malignancy?

Certain drugs, antinuclear antibodies linked to GI dysfunction in SSc

A phenome-wide association study (pheWAS) has found known and potentially new risk factors for gastrointestinal (GI) dysfunction in systemic sclerosis (SSc), which include drug classes such as opioid, antimuscarinic, and endothelin receptor antagonist, and antinuclear antibodies (ANAs) subgroup.

Certain drugs, antinuclear antibodies linked to GI dysfunction in SSc