News &amp; Updates

Treatment with liposomal irinotecan in adults with relapsed small cell lung cancer (SCLC) achieves similar overall survival (OS) when compared with topotecan, but the former is associated with a higher overall response rate (ORR), according to the results of RESILIENT, randomized, open-label phase III trial.

Is liposomal irinotecan superior to topotecan in relapsed small cell lung cancer?

07 Jun 2023

7-day modified fasting therapy improves health, body weight of hospitalized patients

Modified fasting therapy for 7 days is both safe and effective for improving physical health, body weight-related indicators, body composition, and relevant cardiovascular risk factors in hospitalized patients, results of a recent study have shown.

7-day modified fasting therapy improves health, body weight of hospitalized patients

Germline genetic testing registers low numbers

The adoption rate of germline genetic testing among individuals diagnosed with cancer in some states in the US over a period of 6 years remains subpar, with only 6.8 percent undergoing testing, as reported in a study.

Germline genetic testing registers low numbers

Lower rates of relapse and discontinuation with ocrelizumab after natalizumab vs dimethyl fumarate and fingolimod in MS

A retrospective observational cohort study finds that patients with relapsing-remitting multiple sclerosis (RRMS) who switched from natalizumab to ocrelizumab had lower annual relapse and discontinuation rates and longer time to first relapse than those who switched to dimethyl fumarate or fingolimod.

Lower rates of relapse and discontinuation with ocrelizumab after natalizumab vs dimethyl fumarate and fingolimod in MS

Cocoa extract improves memory in older adults with flavanol-poor diet

A large 3-year study of >3,500 older adults finds that flavanol-rich cocoa extract restores memory in participants with low-quality diet or low habitual flavanol consumption.

Cocoa extract improves memory in older adults with flavanol-poor diet

T2DM: SGLT2 inhibitors associated with lower rates of ICU admission and all-cause mortality

A retrospective observational study of nearly 28,000 patients with type 2 diabetes mellitus (T2DM) in Hong Kong finds that use of sodium-glucose cotransporter 2 (SGLT2) inhibitors is independently associated with lower rates of ICU admission and all-cause mortality across various disease categories.

T2DM: SGLT2 inhibitors associated with lower rates of ICU admission and all-cause mortality

07 Jun 2023

Organ sparing may predispose genitourinary rhabdomyosarcoma patients to extra surgery

Patients with genitourinary rhabdomyosarcoma who undergo organ-sparing treatment have higher odds of additional reconstructive surgery due to compromised urological function, reports a study.

Organ sparing may predispose genitourinary rhabdomyosarcoma patients to extra surgery

Tofacitinib safe, effective in UC, but response fades after dose reduction

06 Jun 2023 by

Treatment with tofacitinib is both safe and effective in a real-world setting, as shown in a Canada study, in which a third of patients with ulcerative colitis (UC) achieved clinical remission with few serious adverse events. However, nearly half of them have lost response following dose de-escalation, and this is only partially recaptured with re-escalation.

Tofacitinib safe, effective in UC, but response fades after dose reduction

Does extended lymph node sampling increase complications?