News &amp; Updates

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

21 Dec 2021 by

The angiotensin receptor-neprilysin inhibitors (ARNI) sacubitril/valsartan does not appear to help manage heart failure (HF) in Asian patients with adult congenital heart disease (ACHD), with a small study from Singapore showing that the drug can only be tolerated at suboptimal doses and that hypotension prevents uptitration.

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

Treatment with high-dose continuous intravenous labetalol (HD-CIVL) results in a nonstatistically significant higher incidence of haemodynamic instability compared to an esmolol combination (EC) regimen in patients with type B aortic dissections (TBADs), results of a study have shown.

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

TAF useful in pregnant women with chronic hepatitis B infection

Treatment with tenofovir alafenamide (TAF) for pregnant women with active chronic hepatitis B (CHB) infection, when administered throughout or initiated early in pregnancy, is effective and safe in both mothers and infants, according to a study.

TAF useful in pregnant women with chronic hepatitis B infection

20 Dec 2021

Antithyroid drug therapy in pregnant women poses modest risk of congenital anomalies

Exposure to thionamide antithyroid drugs (ATDs) during pregnancy contributes to a small increase in the risk of congenital anomalies, according to the results of a systematic review and meta-analysis.

Antithyroid drug therapy in pregnant women poses modest risk of congenital anomalies

Coffee good – or bad – for the heart

20 Dec 2021 by

Daily coffee intake is tied to increased physical activity and incidence of premature ventricular contractions (PVCs) but fewer episodes of supraventricular tachycardia (SVT) and less nighttime sleep in the CRAVE* trial.

Coffee good – or bad – for the heart

Original New Drug Application Approvals by US FDA (01-15 December 2021)

19 Dec 2021

New drug applications approved by US FDA as of 01-15 December 2021 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01-15 December 2021)

19 Dec 2021

Pfizer's COVID-19 antiviral pills yield EPIC results for hospitalization, deaths

19 Dec 2021 by

A new oral COVID-19 antiviral therapy comprising nirmatrelvir and ritonavir substantially slashes the risk of hospitalization or death compared with placebo in nonhospitalized adults with COVID-19 who are at high risk of developing severe illness, according to final analysis of the EPIC-HR* study.

Pfizer's COVID-19 antiviral pills yield EPIC results for hospitalization, deaths

19 Dec 2021

Tadalafil plus antihypertensives yield no excess risk of hypotension, cardiac events

The use of tadalafil with antihypertensive medications does not seem to cause an excess risk of hypotensive or cardiovascular outcomes in men with erectile dysfunction (ED), a recent real-world study has found.

Tadalafil plus antihypertensives yield no excess risk of hypotension, cardiac events

HPV vaccine prevents high-grade cervical lesion in population with low vaccination uptake

The human papillomavirus (HPV) vaccine helps protect against the risk of developing high-grade cervical lesion even in a population with low vaccination coverage, as shown in a study.

HPV vaccine prevents high-grade cervical lesion in population with low vaccination uptake