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Pituitary-targeting seliciclib shows promise in treatment of Cushing disease
In a recent study, seliciclib therapy demonstrates its potential in reversing hypercortisolism by directly targeting pituitary corticotrophs in Cushing disease (CD). However, the agent is associated with liver toxicity, which is resolved by withdrawing treatment.
Pituitary-targeting seliciclib shows promise in treatment of Cushing disease
15 Mar 2023
TKI therapy may improve survival in metastatic pheochromocytomas/paragangliomas
Treatment with tyrosine kinase inhibitors (TKIs), such as sunitinib, provides survival benefits to patients with metastatic pheochromocytomas/paragangliomas (PPGLs), suggests a recent study.
TKI therapy may improve survival in metastatic pheochromocytomas/paragangliomas
15 Mar 2023
Add-on evolocumab improves plaque characteristics in statin-treated CAD patients
In individuals with stable coronary artery disease (CAD), intensifying their lipid-lowering regimen with evolocumab, a PCSK9* inhibitor, led to improvements in coronary plaque characteristics on intravascular imaging, findings from the YELLOW III trial have shown.
Add-on evolocumab improves plaque characteristics in statin-treated CAD patients
15 Mar 2023
NEPA- and olanzapine-based regimens similarly effective at preventing CINV in early BC
In a post hoc analysis of two prospective studies, netupitant/palonosetron (NEPA) combined with dexamethasone has demonstrated similar efficacy vs a quadruplet regimen of olanzapine, aprepitant, ondansetron, and dexamethasone in preventing chemotherapy-induced nausea and vomiting (CINV) in Chinese women with early breast cancer (BC) receiving doxorubicin/cyclophosphamide (AC) in Hong Kong.
NEPA- and olanzapine-based regimens similarly effective at preventing CINV in early BC
15 Mar 2023
Looking on the bright side helps with poststroke recovery
When it comes to functional recovery after stroke, the adage “always look on the bright side” appears to be true, with a recent study providing evidence that optimism is associated with better recovery.