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Acid suppression drugs counteract EGFR-TKIs for NSCLC treatment
Acid suppression (AS) medications, such as proton pump inhibitors (PPIs) and histamine type-2 receptor antagonists (H2RAs), weaken the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in nonsmall cell lung cancer (NSCLC), resulting in worse survival outcomes, according to a recent Singapore meta-analysis.
Acid suppression drugs counteract EGFR-TKIs for NSCLC treatment
07 Oct 2021Novel drug helps lessen liver stiffness in high-risk NAFLD
Treatment with the novel, selective peroxisome proliferator-activated receptor α modulator (SPPARMα) pemafibrate appears to produce a significant reduction in liver stiffness but not in liver fat content in patients with high-risk nonalcoholic fatty liver disease (NAFLD), according to the results of a phase II trial.
Novel drug helps lessen liver stiffness in high-risk NAFLD
07 Oct 2021Noncardiac surgery after stenting ups myocardial infarction risk in ACS, SAP patients
In patients with acute coronary syndrome (ACS) or stable angina pectoris (SAP), undergoing noncardiac surgery after stenting increases the risk of myocardial infarction (MI), but only when procedures are performed during acute admission, a recent study has found.
Noncardiac surgery after stenting ups myocardial infarction risk in ACS, SAP patients
07 Oct 2021Bicycling beneficial to patients with Parkinson’s disease
Patients with Parkinson’s disease may do well to ride a bicycle as this helps improve motor performance, especially crucial features of the gait, as reported in a study.
Bicycling beneficial to patients with Parkinson’s disease
07 Oct 2021CV safety of degarelix vs leuprolide: Results remain inconclusive
In men with prostate cancer and concomitant atherosclerotic cardiovascular disease (ASCVD), major adverse cardiovascular event (MACE) incidence did not differ between those who were treated with degarelix or leuprolide, according to findings of the PRONOUNCE trial.
CV safety of degarelix vs leuprolide: Results remain inconclusive
06 Oct 2021Functional abdominal pain in IBD kids in remission worsens fatigue, HR-QoL
Functional abdominal pain among inflammatory bowel disease children in remission (IBP-FAPD) is common and leads to worse fatigue and lower health-related quality of life (HR-QoL), a recent study has found. Past disease severity does not significantly predict IBP-FAPD.
Functional abdominal pain in IBD kids in remission worsens fatigue, HR-QoL
06 Oct 2021Early antiviral treatment shortens hospitalization in kids with flu, comorbidities
Prompt empiric antiviral treatment in children hospitalized for influenza and with high-risk medical conditions or in children admitted to an intensive care unit (ICU) leads to early discharge, as shown in a study.
Early antiviral treatment shortens hospitalization in kids with flu, comorbidities
06 Oct 2021SG Shield confers protection during COVID-19 swab tests
A manikin study has shown that use of the standard face shield is not enough to protect against droplet dispersion during oropharyngeal COVID-19 swabs, but the SG Shield results in significant reduction of droplet contamination to the swab provider’s face and chest.