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Pulmonary arterial hypertension outcomes better with early therapy augmentation with selexipag
In the treatment of patients with pulmonary arterial hypertension, adding selexipag as a third medication sooner rather than later is crucial to help prevent hospitalization and disease progression, as suggested in an emulated target trial.

Can neurologic manifestations predict poor outcomes in young SARS-CoV-2, MIS-C patients?
A prospective cohort study has shown that in patients aged <18 years hospitalized for acute SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C), neurologic manifestations during the infection are common and may predispose them more to new neurocognitive or functional morbidity at discharge.

Is it safe to use pyrazinamide in older patients with TB?
Adding pyrazinamide (PZA) to the initial tuberculosis (TB) treatment in older patients may lead to an increase in the incidence of adverse events (AEs), particularly allergic reactions, but not in-hospital mortality, length of hospital stay, or hepatotoxicity, reports a study, which used data from the Japanese Diagnosis Procedure Combination inpatient database.

Benralizumab offers sustained remission in severe eosinophilic asthma
Treatment with benralizumab (BRZ) results in sustained remission in patients with severe eosinophilic asthma (SEA), particularly those with comorbid chronic rhinosinusitis with nasal polyps (CRSwNP) and reversible airflow limitation, reports a study.





