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Epinephrine improves certain out-of-hospital cardiac arrest survival outcomes

02 Feb 2023

Epinephrine, given either at standard or high dose or in combination with vasopressin during out-of-hospital cardiac arrest (OHCA) resuscitation, leads to more favourable return of spontaneous circulation (ROSC) and survival to hospital admission but not survival to discharge or functional outcome, according to a study.

02 Feb 2023

Antibiotic prophylaxis for primary penile implantation tied to higher infection risk

02 Feb 2023

Antibiotic prophylaxis with vancomycin plus gentamicin alone for primary inflatable penile prosthesis surgery results in a higher risk of infection compared to nonstandard antibiotic regimens, suggests a recent study. On the other hand, antifungal use appears to reduce infection risk.

02 Feb 2023

Preop chemotherapy confers survival advantage in colorectal cancer with liver metastasis

02 Feb 2023 by

Giving chemotherapy to patients with synchronous and unresectable liver metastases from colorectal cancer before undergoing primary tumour resection helps boost survival outcomes, according to a phase III trial presented at this year’s ASCO Gastrointestinal Cancer Symposium (ASCO GI).

02 Feb 2023

Tigulixostat for lowering uric acid scores high in phase II trial

01 Feb 2023

Treatment with the nonpurine xanthine oxidase inhibitor tigulixostat leads to a significant reduction in serum uric acid (sUA) levels while having an acceptable safety profile, as shown in data from the multicentre, double-blind, parallel-group, dose-finding phase II CLUE trial.

01 Feb 2023

Indomethacin plus somatostatin helps avert pancreatitis in ERCP patients

01 Feb 2023

The addition of somatostatin to rectal indomethacin is safe and effective in the prevention of postendoscopic retrograde cholangiopancreatography (post-ERCP) hypermylasemia and pancreatitis (PEP) in high-risk patients, reports a study.

01 Feb 2023

Study supports safety of fourth BNT162b2 mRNA vaccine

01 Feb 2023 by

A study from Israel validated the safety of the fourth BNT162b2 mRNA COVID-19 vaccine (ie, second booster) using data from a retrospective and a prospective cohort.

01 Feb 2023

Bionic pancreas better controls glucose levels than standard care in T1D

31 Jan 2023 by

Insulin delivery via a bionic pancreas better controlled HbA_1clevels compared with standard of care (SoC) in patients with type 1 diabetes (T1D), according to a recent multicentre trial from the US.

31 Jan 2023

Original New Drug Application Approvals by US FDA (16-31 January 2023)

31 Jan 2023

New drug applications approved by US FDA as of 16-31 January 2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

31 Jan 2023