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Which factors predict progression from discoid lupus to severe SLE?
A diagnosis of discoid lupus erythematosus (DLE) at age 25 years or below, phototype V to VI, and antinuclear antibody titers of ≥1:320 are significantly associated with the development of severe systemic lupus erythematosus (SLE), according to a study.

Short-term risk of certain cancers similar in RA, PsA patients treated with JAK, TNF inhibitors
For patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA), initiation of Janus kinase (JAK) inhibitor treatment does not carry a higher short-term risk of cancer, with the exception of nonmelanoma skin cancer (NMSC), as compared with initiation of biological disease-modifying antirheumatic drugs (bDMARDs) including tumour necrosis factor (TNF) inhibitors, according to a study.

Vaccination offers protection to AIIRD patients, but only a few get vaxxed
Vaccines are safe and effective in patients with autoimmune inflammatory rheumatic disease (AIIRD), according to several physicians who participated in a recent international survey. However, many of the respondents are also responsible for not encouraging their patients to get vaccinated.

How common is viral burden rebound in hospitalized COVID-19 patients with or without oral antiviral treatment?
A real-world study during Hong Kong’s Omicron BA.2.2 wave has shown that viral burden rebound is uncommon in hospitalized COVID-19 patients not requiring supplemental oxygen on admission, regardless of whether they were treated with nirmatrelvir/ritonavir or molnupiravir. However, immunocompromised patients, regardless of oral antiviral use, are more likely to have viral burden rebound.





