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SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC

SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC

10 Sep 2023

Epidermal growth factor receptor (EGFR)-mothers against decapentaplegic homologue 7 (SMAD7)-Chimeric antigen receptor (CAR) T-cell therapy against nonsmall-cell lung cancer (NSCLC) is on a par with EGFR-dominant‒negative transforming growth factor (TGFbeta) receptor 2 (DNR)-CAR-T in terms of efficacy and resistance to negative TGFβ regulation, a study has shown.

10 Sep 2023
Hydrocortisone cuts mortality risk in ICU patients with severe pneumonia

Hydrocortisone cuts mortality risk in ICU patients with severe pneumonia

08 Sep 2023 byAudrey Abella

In patients admitted to the intensive care unit (ICU) for severe community-acquired pneumonia (CAP), those who received hydrocortisone had a lower mortality risk compared with those on placebo, findings from the CAPE COD* trial suggest.

08 Sep 2023
Severe bronchiolitis in infancy tied to reduced lung function in childhood

Severe bronchiolitis in infancy tied to reduced lung function in childhood

07 Sep 2023

Infants with severe bronchiolitis are at heightened risk of having decreased lung function at age 6 years, according to a study.

07 Sep 2023