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Response analysis further establishes tezepelumab benefit in severe uncontrolled asthma
Adolescents and adults with severe uncontrolled asthma while on inhaled corticosteroids (ICS) had greater responses to the human monoclonal antibody tezepelumab than placebo, according to prespecified exploratory results of the phase III NAVIGATOR trial.

Antibody responses to COVID-19 vaccines in older people: Recent evidence & local data
Older adults have weaker antibody responses to two doses of COVID-19 vaccines [ie, mRNA-based BNT162b2 vaccine and inactivated CZ02 vaccine] vs younger individuals, but a booster dose mounts SARS-CoV-2 neutralization activities to a high level, according to data presented at AIM 2022.

How effective were oral antivirals during HK’s Omicron BA.2 wave?
A real-world study during Hong Kong’s Omicron BA.2 wave showed that both molnupiravir and nirmatrelvir/ritonavir effectively lowered the risks of disease progression and all-cause mortality in hospitalized COVID-19 patients not requiring oxygen supplementation on admission. However, mortality risk reduction was larger with nirmatrelvir/ritonavir vs molnupiravir.

Change in serum marker levels tied to outcomes of RA-related interstitial lung disease
In rheumatoid arthritis-related interstitial lung disease (RA-ILD), change over time in the levels of serum proteins, such as matrix metallopeptidase 13 (MMP13) and C-X-C motif ligand chemokine 11 (CXCL11), predict clinical outcomes, a recent study has found. The same is true for baseline clinical factors such as patient age and rheumatoid factor.




