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BPaL regimen tied to liver injury

10 Apr 2025

The overall risk of drug-induced liver injury (DILI) with the pretomanid, bedaquiline and linezolid (BPaL) regimen is lower compared with the isoniazid, rifampin, pyrazinamide and ethambutol (HRZE) regimen, a study has shown. However, the association between BPal and DILI remains significant, suggesting the need for careful monitoring during treatment.

BPaL regimen tied to liver injury

10 Apr 2025

Amlodipine makes up half of CCB overdoses; verapamil, diltiazem remain most toxic

09 Apr 2025 by

Among the cases of calcium channel blocker (CCB) overdose, dihydropyridines are the most common, with amlodipine accounting for nearly half. On the other hand, more severe toxicities occur with the use of verapamil and diltiazem.

Amlodipine makes up half of CCB overdoses; verapamil, diltiazem remain most toxic

09 Apr 2025

Esketamine may work against treatment-resistant depression

04 Apr 2025

Treatment with esketamine as an add-on to antidepressants shows modest efficacy in adults with treatment-resistant depression, reports a study. Its effect on suicidality, however, is not significant.

Esketamine may work against treatment-resistant depression

04 Apr 2025

Ganciclovir/valganciclovir tied to adverse effects in preterm infants with CMV

03 Apr 2025 by

Preterm and very low birthweight (VLBW) infants who have been treated with ganciclovir (GCV) or oral valganciclovir (valGCV) for cytomegalovirus (CMV) disease are more likely to experience adverse events than term infants, a study has shown.

Ganciclovir/valganciclovir tied to adverse effects in preterm infants with CMV

03 Apr 2025

Cetuximab linked to pocket infections after central venous port placement

02 Apr 2025

Cetuximab therapy appears to induce skin complications in patients following central venous port placement, reports a study.

Cetuximab linked to pocket infections after central venous port placement

02 Apr 2025

Tirzepatide lowers HbA1c, body weight in adults with T2D

01 Apr 2025 by

Treatment with tirzepatide once weekly results in significant decreases in glycated haemoglobin A1c (HbA1c) and body weight (BW), regardless of antiglutamic acid decarboxylase autoantibodies (GADA) status in adults with type 2 diabetes (T2D), according to a post hoc analysis of SURPASS.

Tirzepatide lowers HbA1c, body weight in adults with T2D

01 Apr 2025

Maternal TDF, infant HBV vax, HBIg-free strategy prevent infant hep B

01 Apr 2025 by

In the absence of infant hepatitis B immune globulin (HBIg), maternal tenofovir disoproxil fumarate (TDF) prophylaxis combined with infant hepatitis B virus (HBV) immunization provide sufficient protection against HBV infection in infants, findings from the iTAP-2 study suggest. However, the risk of infection was not demonstrably below 2 percent.

Maternal TDF, infant HBV vax, HBIg-free strategy prevent infant hep B

01 Apr 2025

Fluoxetine boosts good cholesterol, lowers triglycerides in people with obesity

31 Mar 2025

The selective serotonin reuptake inhibitor fluoxetine appears to modify lipid profile in individuals with overweight or obesity, with triglyceride levels reduced and high-density lipoprotein cholesterol (HDL-C) levels increased, according to a systematic review and meta-analysis.

Fluoxetine boosts good cholesterol, lowers triglycerides in people with obesity

31 Mar 2025

Biosimilar as safe, effective as ustekinumab in plaque psoriasis

31 Mar 2025

The biosimilar BAT2206 demonstrates similar efficacy, safety, pharmacokinetics, and immunogenicity to its reference drug, ustekinumab (UST), in a recent phase III trial.

Biosimilar as safe, effective as ustekinumab in plaque psoriasis

31 Mar 2025

Phenobarbital use after BZD safe, effective for alcohol withdrawal

31 Mar 2025

Phenobarbital (PHB) may be used if patients remain in uncontrolled alcohol withdrawal syndrome (AWS) following treatment with benzodiazepines (BZD), suggests a study.

Phenobarbital use after BZD safe, effective for alcohol withdrawal

31 Mar 2025

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BPaL regimen tied to liver injury

BPaL regimen tied to liver injury

Amlodipine makes up half of CCB overdoses; verapamil, diltiazem remain most toxic

Amlodipine makes up half of CCB overdoses; verapamil, diltiazem remain most toxic

Esketamine may work against treatment-resistant depression

Esketamine may work against treatment-resistant depression

Ganciclovir/valganciclovir tied to adverse effects in preterm infants with CMV

Ganciclovir/valganciclovir tied to adverse effects in preterm infants with CMV

Cetuximab linked to pocket infections after central venous port placement

Cetuximab linked to pocket infections after central venous port placement

Tirzepatide lowers HbA1c, body weight in adults with T2D

Tirzepatide lowers HbA1c, body weight in adults with T2D

Maternal TDF, infant HBV vax, HBIg-free strategy prevent infant hep B

Maternal TDF, infant HBV vax, HBIg-free strategy prevent infant hep B

Fluoxetine boosts good cholesterol, lowers triglycerides in people with obesity

Fluoxetine boosts good cholesterol, lowers triglycerides in people with obesity

Biosimilar as safe, effective as ustekinumab in plaque psoriasis

Biosimilar as safe, effective as ustekinumab in plaque psoriasis

Phenobarbital use after BZD safe, effective for alcohol withdrawal

Phenobarbital use after BZD safe, effective for alcohol withdrawal