News &amp; Updates

Researchers from the Chinese University of Hong Kong (CUHK) have reported that two doses of either mRNA-based BNT162b2 or inactivated CZ02 vaccine elicit cross-reactive T-cell responses. Identification of vaccine-induced memory T cells indicates potential long-term protection with COVID-19 vaccines.

COVID-19 vaccines may elicit cross-reactive T-cell responses for long-term protection

01 Aug 2023

Air pollution a hazard to pregnant women and their babies

Exposure to traffic-related air pollution may put pregnant women at risk of delivering preterm and the babies at risk of neonatal intensive care unit (NICU) admissions and low birthweight, among others, as reported in a study.

Air pollution a hazard to pregnant women and their babies

Plasma EBV DNA analysis may predict future NPC risk

Plasma Epstein-Barr virus (EBV) DNA analysis not only identifies asymptomatic early-stage nasopharyngeal carcinoma (NPC), but also indicates NPC risk in the next 3–5 years, researchers from the Chinese University of Hong Kong (CUHK) have reported.

Plasma EBV DNA analysis may predict future NPC risk

Kids with T2D face dreadful complications

Children with type 2 diabetes (T2D) face a strikingly high complication rate as they become young adults, with an 80 percent incidence of at least one vascular complication, as shown in the TODAY* study.

Kids with T2D face dreadful complications

Novel oral IL-23R antagonist improves skin lesions in patients with plaque psoriasis

Treatment with JNJ-77242113, an oral interleukin-23 receptor (IL-23R) antagonist peptide, leads to significant improvement in skin lesions, as measured by the Psoriasis Area and Severity Index (PASI) scores, in patients with moderate-to-severe plaque psoriasis, according to the FRONTIER 1 study presented at WCD 2023.

Novel oral IL-23R antagonist improves skin lesions in patients with plaque psoriasis

Which factor predicts successful interval extension in eyes with nAMD switched to brolucizumab?

In patients with neovascular age-related macular degeneration (nAMD) who switched to brolucizumab treatment, those with shorter treatment interval before switching are more likely to have successful injection interval extension, as shown in a study.

Which factor predicts successful interval extension in eyes with nAMD switched to brolucizumab?

31 Jul 2023

Phase II data underpin potential of novel triplet for cystic fibrosis

31 Jul 2023 by

Two phase II studies showed favourable signals for vanzacaftor, tezacaftor, and deutivacaftor (VX-121/TEZ/D-IVA) – a novel triplet regimen for cystic fibrosis (CF) – which could be an alternative to elexacaftor, tezacaftor, and ivacaftor (ELX/TEZ/IVA).

Phase II data underpin potential of novel triplet for cystic fibrosis

Multidisciplinary molecular tumour board–guided treatment prolongs survival in advanced solid cancers

31 Jul 2023 by

A multidisciplinary molecular tumour board (MTB) successfully integrates next-generation sequencing (NGS) comprehensive gene profiling (CGP) into real-world clinical practice to guide treatment and significantly extend overall survival (OS) in patients with heavily pretreated advanced solid cancers, a study by researchers from the University of Hong Kong (HKU) has shown.

Multidisciplinary molecular tumour board–guided treatment prolongs survival in advanced solid cancers

Dengue’s Lingering Impact: Investigating the Chronic Consequences of Dengue Infection

Dengue is endemic in the tropical and sub-tropical regions of the world and afflicts an estimated 100million people each year. The acute infection typically resolves on its own within 7–10 days. In certain instances, however, the infection may lead to longer-term chronic sequelae, which we term here as “long dengue”. Similar post-infectious syndromes have also been observed following other viral infections, such as COVID-19. Among patients with long dengue, chronic fatigue, characterised by persistent fatigue and malaise, is often one of the most prominent symptoms, and can persist for weeks or even months after acute infection. Other potential effects may include concentration impairment, and even depression. The incidence and severity of these chronic sequelae vary between individuals.

Dengue’s Lingering Impact: Investigating the Chronic Consequences of Dengue Infection