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New oral tyrosine kinase 2 inhibitor shows promise against moderate-to-severe plaque psoriasis
PF-06826647, a novel tyrosine kinase 2 inhibitor in development, outperforms placebo at reducing disease severity in patient with moderate-to-severe plaque psoriasis, reveals a new trial.
New oral tyrosine kinase 2 inhibitor shows promise against moderate-to-severe plaque psoriasis
23 Apr 2022Ritlecitinib, brepocitinib show promise against scalp alopecia areata
Ritlecitinib and brepocitinib lead to improvements in scalp alopecia areata and its associated biomarkers, reveals a recent substudy of a phase 2a trial.
Ritlecitinib, brepocitinib show promise against scalp alopecia areata
22 Apr 2022Topical therapy plus microneedling safe, effective in melasma management
Use of microneedling appears to be a beneficial adjunct to topical medications in the treatment of melasma, suggests a recent study.
Topical therapy plus microneedling safe, effective in melasma management
03 Apr 2022Abrocitinib effectively manages AD flares
Rescue therapy using the Janus kinase 1 inhibitor abrocitinib combined with topical medicated therapy recaptured efficacy responses and had a favourable safety profile in individuals with moderate-to-severe atopic dermatitis (AD) who experienced flare during the maintenance period of the phase III randomized-withdrawal JADE REGIMEN trial.
Abrocitinib effectively manages AD flares
21 Mar 2022Antihypertensive drugs up risk of psoriasis
Use of antihypertensive medications is associated with the incidence of psoriasis, reports a study. Beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers (CCBs), and thiazide diuretics result in an increased risk of psoriasis.
Antihypertensive drugs up risk of psoriasis
17 Mar 2022Adalimumab–methotrexate combo better than adalimumab monotherapy in psoriasis
In the treatment of patients with psoriasis, the combination of adalimumab plus methotrexate is more beneficial than adalimumab alone, reducing antidrug antibody formation and inducing slightly better response, drug survival, and higher serum trough concentrations, according to a study.
Adalimumab–methotrexate combo better than adalimumab monotherapy in psoriasis
14 Mar 2022Upadacitinib shows promise for long-term AD treatment
Upadacitinib with topical corticosteroids shows good long-term efficacy and safety in patients with moderate-to-severe atopic dermatitis (AD), reports a recent follow-up analysis to the AD Up study.