News &amp; Updates

In the treatment of osteoporosis among older women who are dialysis-dependent, the use of denosumab appears to result in a much higher incidence of severe and very severe hypocalcaemia when compared with oral bisphosphonates, according to a retrospective cohort study.

Denosumab carries severe hypocalcaemia risk in older female dialysis-dependent patients

Daily oral PrEP regimen remains protective in cisgender women despite missed doses

07 Mar 2024 by

Oral pre-exposure prophylaxis (PrEP) with emtricitabine plus tenofovir disoproxil fumarate (F/TDF) works well to prevent HIV in cisgender women even if daily doses are occasionally missed, according to a study.

Daily oral PrEP regimen remains protective in cisgender women despite missed doses

Pulse vs nonpulse corticosteroid: Which is better against IPF?

In a study presented at AAAAI 2024, epinephrine in preservative-free, nasal powder formulations demonstrated superior stability and comparable plasma exposure to the EpiPen^® autoinjector, thus providing a less-invasive treatment option for severe allergic reactions including anaphylaxis.

Patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) who received a pulse dose of corticosteroids do not appear to have longer survival than those who received conventional nonpulse dose of corticosteroids, results of a study have shown.

Pulse vs nonpulse corticosteroid: Which is better against IPF?

07 Mar 2024

Needle-free epinephrine an alternative for anaphylaxis?

07 Mar 2024 by

Needle-free epinephrine an alternative for anaphylaxis?

07 Mar 2024

Thiazide diuretics, alkali therapy help reduce symptomatic stone events

Adherence to thiazide diuretics among patients with urolithiasis and hypercalciuria leads to fewer symptomatic stone events, as does adherence to alkali therapy among those with low urine pH, according to a retrospective cohort study.

Thiazide diuretics, alkali therapy help reduce symptomatic stone events

Topical diclofenac offers no benefit over oral ibuprofen for acute low back pain

Topical diclofenac does not appear to significantly improve functional outcome in acute musculoskeletal low back pain as compared with oral ibuprofen, with no added benefit when co-administered with oral ibuprofen, according to a study.

Topical diclofenac offers no benefit over oral ibuprofen for acute low back pain

Original New Drug Application Approvals by US FDA (16-29 February 2024)

New drug applications approved by US FDA as of 16-29 February 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-29 February 2024)

Cannabis use detrimental to heart health

05 Mar 2024 by

Cannabis users may be putting themselves at risk of adverse cardiovascular outcomes, with the risk increasing proportionately with the frequency of use.

Cannabis use detrimental to heart health

Extraoral manifestation not uncommon in osteonecrosis of the jaw

Medication-related osteonecrosis of the jaw (MRONJ), a major side effect of using bone-modifying agents (BMA) for cancer or osteoporosis, normally manifests intraorally. However, some patients may have an extraoral manifestation of erythematous swelling or fistulas localized to the jaw area, according to a recent study.

Extraoral manifestation not uncommon in osteonecrosis of the jaw

Ramipril on par with sacubitril/valsartan in acute MI