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Dose-capping chemoradiotherapy tied to higher recurrence in rectal cancer
The risk of disease recurrence is increased among rectal cancer patients treated with dose-capped chemoradiotherapy (CRT), reveals a study. In addition, excessive toxicity has occurred among those dosed by actual body surface area (BSA) compared to patients in the dose-capped group.

Prompt antibiotic treatment prevents surgery in preseptal, orbital cellulitis
Differential diagnosis of preseptal and orbital cellulitis show “extremely sensitive” clinical presentation and C-reactive protein (CRP), according to a study, noting that prompt initiation of intravenous antibiotics is required and helps prevent surgical procedures even in those with incipient abscesses.

Novel score predicts survival, radiological response in HCC
The novel CRAFITY score—which takes into account C-reactive protein (CRP), alpha-foetoprotein (AFP), and immunotherapy—can be used to reliably assess survival and radiological response in hepatocellular carcinoma (HCC), a recent study has found. Future validation is needed before CRAFITY can be deployed to the clinics.

Higher serum uric acid translates to greater CV disease burden in chronic coronary syndromes
Among patients with chronic coronary syndromes, those with higher serum uric acid (SUA) levels are more likely to have major adverse cardiovascular (CV) events (MACE) and worse related quality of life (QoL), as reported in a study.

Environmental contaminants impair liver metabolism, leading to NAFLD
Exposure to environmental contaminants, particularly perfluorinated alkyl substances, seems to disrupt bile acid and lipid metabolism, both key hepatic metabolic pathways that are known to be dysregulated in nonalcoholic fatty liver disease (NAFLD), a recent study has found. Such an effect seems to be more pronounced in women.




