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Mutations affect efficacy of avelumab in advanced endometrial cancer

09 Jul 2024

Avelumab immunotherapy may perform poorly in advanced endometrial cancer (EC) patients with TP53 mutation but has positive effects in those with mutations of PTEN and ARID1A, suggest the results of the MITO END-3 trial.

Mutations affect efficacy of avelumab in advanced endometrial cancer

09 Jul 2024

Follow-up testing in cervical cancer screening remains low in SG

03 Jul 2024 by

A recent study has found an “unacceptably low” compliance of follow-up following abnormal human papillomavirus (HPV) tests among women in Singapore.

Follow-up testing in cervical cancer screening remains low in SG

03 Jul 2024

Vaginal estrogen therapy safe for some breast cancer patients, but may pose risk for others

02 Jul 2024 by

Vaginal estrogen therapy may be safely used to treat genitourinary symptoms in early-stage breast cancer patients with HR-negative tumours and in those concurrently treated with tamoxifen, according to the results of a target trial emulation. However, its use may be detrimental to disease-free survival (DFS) outcomes in patients receiving aromatase inhibitors.

Vaginal estrogen therapy safe for some breast cancer patients, but may pose risk for others

02 Jul 2024

Exercise boosts sexual health in metastatic breast cancer patients

01 Jul 2024 by

Working out can improve sexual function as well as reduce endocrine sexual symptoms in patients with metastatic breast cancer (mBC), according to data from the PREFERABLE-EFFECT trial.

Exercise boosts sexual health in metastatic breast cancer patients

01 Jul 2024

Organic pollutants found in Mediterranean diet up GDM risk

01 Jul 2024 by

Adherence to a healthy dietary pattern, such as the Mediterranean diet (MedDiet), may reduce the risk of gestational diabetes mellitus (GDM) but appears to increase exposure to harmful chemicals, according to a Singapore study presented at ADA 2024.

Organic pollutants found in Mediterranean diet up GDM risk

01 Jul 2024

High cola drink intake ups risk of GDM

26 Jun 2024

Consuming cola drinks in high amounts during pregnancy may increase the risk of gestational diabetes mellitus (GDM), while moderate caffeine intake appears to exert a nonsignificant protective effect, as shown in the Kuopio Birth Cohort (KuBiCo).

High cola drink intake ups risk of GDM

26 Jun 2024

Sildenafil cream for female sexual arousal disorder may benefit only a subset of women

25 Jun 2024 by

Topical sildenafil cream appears to deliver promising outcomes for premenopausal women with sexual arousal disorder with or without concomitant decreased sexual desire, with increased arousal and reduced sexual distress, according to the results of an exploratory post hoc efficacy analysis of a phase IIb trial.

Sildenafil cream for female sexual arousal disorder may benefit only a subset of women

25 Jun 2024

Does paternal use of metformin up risk for congenital malformations?

21 Jun 2024

Use of metformin monotherapy by fathers during the sperm development period prior to conception does not appear to contribute to an increased risk of major congenital malformations (MCMs) in newborns, reveals a study.

Does paternal use of metformin up risk for congenital malformations?

21 Jun 2024

Original New Drug Application Approvals by US FDA (1-15 June 2024)

21 Jun 2024

New drug applications approved by US FDA as of 1-15 June 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (1-15 June 2024)

21 Jun 2024

PANTHER 10-year data support tailored dose-dense adjuvant chemo for high-risk early breast cancer

18 Jun 2024 by

Long-term data from the phase III PANTHER trial demonstrate improved breast cancer recurrence-free survival (BCRFS) with tailored dose-dense adjuvant chemotherapy as opposed to standard adjuvant chemo in individuals with high-risk early breast cancer.

PANTHER 10-year data support tailored dose-dense adjuvant chemo for high-risk early breast cancer

18 Jun 2024

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Mutations affect efficacy of avelumab in advanced endometrial cancer

Mutations affect efficacy of avelumab in advanced endometrial cancer

Follow-up testing in cervical cancer screening remains low in SG

Follow-up testing in cervical cancer screening remains low in SG

Vaginal estrogen therapy safe for some breast cancer patients, but may pose risk for others

Vaginal estrogen therapy safe for some breast cancer patients, but may pose risk for others

Exercise boosts sexual health in metastatic breast cancer patients

Exercise boosts sexual health in metastatic breast cancer patients

Organic pollutants found in Mediterranean diet up GDM risk

Organic pollutants found in Mediterranean diet up GDM risk

High cola drink intake ups risk of GDM

High cola drink intake ups risk of GDM

Sildenafil cream for female sexual arousal disorder may benefit only a subset of women

Sildenafil cream for female sexual arousal disorder may benefit only a subset of women

Does paternal use of metformin up risk for congenital malformations?

Does paternal use of metformin up risk for congenital malformations?

Original New Drug Application Approvals by US FDA (1-15 June 2024)

Original New Drug Application Approvals by US FDA (1-15 June 2024)

PANTHER 10-year data support tailored dose-dense adjuvant chemo for high-risk early breast cancer

PANTHER 10-year data support tailored dose-dense adjuvant chemo for high-risk early breast cancer