News &amp; Updates

A recent study has found no significant link between gynephilia and nonheterosexuality in women, who also seem to exhibit greater fluidity in sexual preferences and behaviours than men.

Women more fluid in sexual preference than men, says study

In the 7-year update of the phase III ALESIA trial, alectinib outdoes crizotinib for Asian patients with treatment-naïve, advanced or metastatic ALK+ non-small-cell lung cancer (NSCLC).

Alectinib trumps crizotinib for ALK+ NSCLC

13 Jan 2025 by

Alectinib trumps crizotinib for ALK+ NSCLC

13 Jan 2025

Sex does not impact endovascular thrombectomy outcomes

In the treatment of patients presenting with large ischaemic stroke, endovascular thrombectomy (EVT) is beneficial to both women and men, with higher rates of functional independence and independent ambulation relative to medical management, according to a study.

Sex does not impact endovascular thrombectomy outcomes

Overall outlook for paediatric sickle cell disease improved with stem cell transplant

12 Jan 2025 by

Allogeneic stem cell transplantation (allo-SCT) appears to confer lasting benefits to children with sickle cell anaemia and a history of abnormal cerebral velocities, with substantial improvements in quality of life (QoL) and cognitive outcomes 10 years later, according to the results of the DREPAGREFFE-2 trial.

Overall outlook for paediatric sickle cell disease improved with stem cell transplant

Radiofrequency ablation of vaginal canal relieves GSM symptoms

The use of radiofrequency ablation of the vaginal canal by the MorpheusV applicator helps reduce symptoms of genitourinary syndrome of menopause (GSM), which include burning, dryness, dyspareunia, and irritative lower urinary tract symptoms, according to a study.

Radiofrequency ablation of vaginal canal relieves GSM symptoms

Metformin may reduce asthma attacks

The glucose-lowering drug metformin appears to be associated with fewer asthma attacks, with further reductions when metformin is used in combination with GLP-1RAs, according to a study.

Metformin may reduce asthma attacks

Consolidative stem cell transplant may be skipped for MCL patients with undetectable disease

11 Jan 2025 by

In patients with mantle cell lymphoma (MCL) who have achieved complete remission and undetectable minimal residual disease (MRD) following initial therapy, autologous hematopoietic cell transplantation (auto-HCT) confers no survival advantage when compared with maintenance therapy alone, as shown in the interim results of the phase III ECOG-ACRIN EA4151 trial.

Consolidative stem cell transplant may be skipped for MCL patients with undetectable disease

Ustekinumab levels higher in IBD patients with normal CRP, endoscopic healing

Patients with inflammatory bowel disease (IBD) who achieve a normal C-reactive protein (CRP) and endoscopic healing exhibit significantly higher ustekinumab trough levels, reveals a study. A cutoff level of 4.8 µg/mL predicts CRP normalization.

Ustekinumab levels higher in IBD patients with normal CRP, endoscopic healing

Anti-CGRP monoclonal antibodies pose no increased CVD risk

Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) or its receptor do not appear to contribute to heightened risk of cardiovascular disease (CVD) relative to onabotulinumtoxinA in adults with migraine at high CVD risk, according to a study.

Anti-CGRP monoclonal antibodies pose no increased CVD risk