News &amp; Updates

Co-administration of piperacillin and tazobactam (PIPC/TAZ) does not result in delayed methotrexate (MTX) clearance during high-dose MTX therapy, a study has shown. In addition, co-administration of cefepime with high-dose MTX had no impact on MTX clearance.

Piperacillin-tazobactam combo causes no delay in MTX clearance

Artificial sweeteners up risk of cardiovascular diseases

Higher consumption of artificial sweetener, particularly aspartame, sucralose, and acesulfame potassium, appears to increase the risk of cardiovascular disease (CVD), suggests a study.

Artificial sweeteners up risk of cardiovascular diseases

Does diabetes worsen survival in metastatic breast cancer?

Diabetes does not appear to increase mortality in patients with metastatic breast cancer (MBC), but diabetes and hyperglycaemia both contribute to worse overall survival (OS) in a cohort of longer-term survivors, a study has found.

Does diabetes worsen survival in metastatic breast cancer?

19 Sep 2022

Chinese heart-healthy diet effective for lowering BP in Chinese adults

The cuisine-based Chinese heart-healthy (CHH) diet was effective, palatable, and cost-effective in reducing blood pressure (BP) in Chinese adults with mild hypertension, findings from the DECIDE*-Diet trial suggest.

Chinese heart-healthy diet effective for lowering BP in Chinese adults

19 Sep 2022

Vitamin B12, homocysteine levels tied to neurocognitive decline in healthy adults

Low serum levels of vitamin B12 and high concentrations of homocysteine appears to aggravate the risk of progression to neurocognitive disorder (NCD) among cognitively healthy adults, a recent Singapore study has found.

Vitamin B12, homocysteine levels tied to neurocognitive decline in healthy adults

High-dose treprostinil for PH-ILD yields better outcomes

In the treatment of patients with pulmonary hypertension (PH) with fibrotic interstitial lung disease (ILD), a higher dose of inhaled treprostinil or getting at least nine breaths four times daily increases the likelihood of achieving clinical improvement and preventing clinical worsening, according to a study.

High-dose treprostinil for PH-ILD yields better outcomes

Evolocumab benefits build up in FOURIER OLE

Early, long-term lipid lowering with the PCSK9 inhibitor evolocumab further reduces cardiovascular (CV) events, including CV death, without any safety signal, in the FOURIER* open-label extension (OLE) study.

Evolocumab benefits build up in FOURIER OLE

Tucatinib-trastuzumab combo induces durable tumour response in HER2+ mCRC

Dual HER-2 inhibition with tucatinib and trastuzumab induces clinically meaningful and durable responses in patients with previously treated metastatic HER2-positive colorectal cancer (mCRC) in the phase II MOUNTAINEER trial, boosting hopes for this chemotherapy-free combination.

Tucatinib-trastuzumab combo induces durable tumour response in HER2+ mCRC

Levonorgestrel-releasing intrauterine system delivers prolonged effects

The long-acting contraceptive option, 52-mg levonorgestrel-releasing intrauterine system (52-mg LNG-IUS), appears to be highly effective, with high user satisfaction and a favourable safety profile, through 8 years of use, according to data from the Mirena Extension Trial.

Levonorgestrel-releasing intrauterine system delivers prolonged effects

$Pharmacist-led program improves management of refractory chemo-induced nausea, vomiting$

Pharmacist-led program improves management of refractory chemo-induced nausea, vomiting

Implementing a clinical pharmacist-led service program has led to the standardization and streamlining of refractory chemotherapy-induced nausea and vomiting (CINV) management in adult haematology and oncology clinics, reports a study.

Pharmacist-led program improves management of refractory chemo-induced nausea, vomiting