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Topical JAK inhibitor scores big in CHE

12 Apr 2023 by

Treatment with the investigational, topical pan-JAK inhibitor delgocitinib cream led to significantly greater improvements in efficacy outcomes compared with the vehicle cream in moderate-to-severe chronic hand eczema (CHE) in the pivotal phase III DELTA 1 trial, offering a rational strategy for targeted therapy.

Topical JAK inhibitor scores big in CHE

12 Apr 2023

Exergaming improves neuronal activity and executive function in older adults with dementia

12 Apr 2023 by

Findings of a small randomized trial in older adults with moderate dementia suggest that exergaming may be associated with greater improvements in brain neuronal activity and enhanced executive function task performance than regular aerobic exercise.

Exergaming improves neuronal activity and executive function in older adults with dementia

12 Apr 2023

Melatonin lowers risk of postoperative delirium

11 Apr 2023

For adults undergoing surgery, melatonin appears to help reduce the likelihood of postoperative delirium, according to the results of a meta-analysis.

Melatonin lowers risk of postoperative delirium

11 Apr 2023

How does dapagliflozin affect cardiac function, hormonal responses to exercise?

11 Apr 2023

Growth hormone (GH), compared with catecholamines, appears to be a better facilitator for the change from glucose to fatty acid metabolism following SGLT2 inhibitor use during exercise, reveals a study.

How does dapagliflozin affect cardiac function, hormonal responses to exercise?

11 Apr 2023

Ripretinib improves survival in advanced gastrointestinal stromal tumours

11 Apr 2023 by

Treatment with ripretinib provides a prolonged clinical and radiological benefit in patients with advanced gastrointestinal stromal tumours (GIST) within the expanded access program (EAP) in the UK, as shown in a study presented at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

Ripretinib improves survival in advanced gastrointestinal stromal tumours

11 Apr 2023

Sleeve gastrectomy may weaken bones in youths

11 Apr 2023

Adolescents and young adults who undergo vertical sleeve gastrectomy (VSG) experiences progressive changes in bone health over 2 years and are prone to skeletal fragility, suggests a study.

Sleeve gastrectomy may weaken bones in youths

11 Apr 2023

COVID-19 pandemic takes a toll on parents’ mental health

11 Apr 2023 by

In Singapore, the COVID-19 pandemic and lockdown measures affected parents’ lives and family dynamics, leading to mental health decline, according to a survey.

COVID-19 pandemic takes a toll on parents’ mental health

11 Apr 2023

Trabectedin plus radiotherapy well tolerated in patients with myxoid liposarcoma

11 Apr 2023

A phase II nonrandomized trial of trabectedin in combination with radiotherapy for the treatment of myxoid liposarcoma has failed to meet its endpoint, although this treatment combination appears to be well tolerated in patients.

Trabectedin plus radiotherapy well tolerated in patients with myxoid liposarcoma

11 Apr 2023

Sarecycline effective for acne vulgaris in patients with skin of colour

11 Apr 2023 by

Sarecycline demonstrated efficacy for the treatment of moderate-to-severe facial acne vulgaris in patients with skin of colour, according to a post hoc analysis of two phase III trials presented at AAD 2023.

Sarecycline effective for acne vulgaris in patients with skin of colour

11 Apr 2023

Neuroticism, well-being PGS predict mood, psychotic disorder onset

10 Apr 2023

Polygenic scores (PGS) for neuroticism and subjective well-being are significantly associated with the risk of major mood and psychotic disorders, regardless of family history, but the predictive power of PGS for psychiatric illness is limited when family history is known, reports a study.

Neuroticism, well-being PGS predict mood, psychotic disorder onset

10 Apr 2023

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Topical JAK inhibitor scores big in CHE

Topical JAK inhibitor scores big in CHE

Exergaming improves neuronal activity and executive function in older adults with dementia

Exergaming improves neuronal activity and executive function in older adults with dementia

Melatonin lowers risk of postoperative delirium

Melatonin lowers risk of postoperative delirium

How does dapagliflozin affect cardiac function, hormonal responses to exercise?

How does dapagliflozin affect cardiac function, hormonal responses to exercise?

Ripretinib improves survival in advanced gastrointestinal stromal tumours

Ripretinib improves survival in advanced gastrointestinal stromal tumours

Sleeve gastrectomy may weaken bones in youths

Sleeve gastrectomy may weaken bones in youths

COVID-19 pandemic takes a toll on parents’ mental health

COVID-19 pandemic takes a toll on parents’ mental health

Trabectedin plus radiotherapy well tolerated in patients with myxoid liposarcoma

Trabectedin plus radiotherapy well tolerated in patients with myxoid liposarcoma

Sarecycline effective for acne vulgaris in patients with skin of colour

Sarecycline effective for acne vulgaris in patients with skin of colour

Neuroticism, well-being PGS predict mood, psychotic disorder onset

Neuroticism, well-being PGS predict mood, psychotic disorder onset