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Ribociclib–binimetinib combo safe, effective in NRAS-mutant melanoma
Treatment with the combination of ribociclib plus binimetinib appears to be well tolerated and delivers modest clinical activity in patients with locally advanced or metastatic melanoma harbouring NRAS mutation, according to the results of a phase Ib/II study.
Ribociclib–binimetinib combo safe, effective in NRAS-mutant melanoma
22 Jul 2022Early mortality explains colorectal cancer survival gap between older, young patients
In patients with colorectal cancer (CRC), the survival gap between older and younger patient can largely be attributed to deaths during the first year after resection, a recent study has found.
Early mortality explains colorectal cancer survival gap between older, young patients
20 Jul 2022Weekly dose-dense CT does not confer survival benefit for ovarian cancer patients
In the final analysis of the phase III ICON8* study, a weekly dose-dense chemotherapy (CT) regimen comprising paclitaxel and carboplatin did not improve survival outcomes in women with epithelial ovarian cancer** compared with the standard first-line (1L) paclitaxel-carboplatin regimen given once every 3 weeks (Q3W).
Weekly dose-dense CT does not confer survival benefit for ovarian cancer patients
18 Jul 2022Pembrolizumab looks good for treated, advanced MSI-H/dMMR endometrial cancer
Use of pembrolizumab helps maintain or improve health-related quality of life in patients with previously treated, advanced endometrial cancer characterized by high levels of microsatellite instability (MSI) or deficient mismatch repair (MSI-H/dMMR), according to data from the phase II KEYNOTE-158 study.
Pembrolizumab looks good for treated, advanced MSI-H/dMMR endometrial cancer
18 Jul 2022Is laparoscopic better than open partial nephrectomy for renal tumours?
Patients with renal tumours who have undergone laparoscopic partial nephrectomy (LPN) have shown similar surgical and oncologic outcomes as those treated with open partial nephrectomy (OPN), reports a study.
Is laparoscopic better than open partial nephrectomy for renal tumours?
17 Jul 2022Mood, anxiety disorders may prolong hospital stay following radical cystectomy
For bladder cancer patients scheduled to undergo radical cystectomy, the presence of mood and/or anxiety disorders may lead to a longer length of hospital stay and increase the likelihood of discharge to a nonhome facility, a study reports.