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Short-course, high-dose gatifloxacin gets a pass in multidrug-resistant TB with caveat
A short-term treatment regimen based on high-dose gatifloxacin appears to be effective against multidrug- or rifampicin-resistant tuberculosis (TB) but at the cost of increased severe adverse drug reactions, as shown in a study.

AECOPD outcomes unaltered with short-course nonmacrolide therapy
Short-course nonmacrolide therapy in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) appears to have no significant effect on outcomes including mortality, progression to ventilation, readmission rate, or prevalence of adverse drug events, a study has shown.

Child abuse increased during COVID-19 lockdown
Child abuse rates appear to have increased during the lockdowns imposed to control COVID-19 transmission, according to a study from the US presented at the 2021 American Academy of Pediatrics National Conference & Exhibition (AAP 2021).

Repurposing a broad-spectrum antiviral drug may help treat asymptomatic, mild COVID-19
The oral antiviral drug umifenovir, which is used to treat influenza, appears to be beneficial in COVID-19 patients who are asymptomatic or with mild symptoms, with a phase III study showing that the drug is well tolerated and can induce viral clearance within 5 days.

Physical activity decline may predict IPF progression
A decline in daily physical activity (DPA) among patients with idiopathic pulmonary fibrosis (IPF) over a year is noteworthy and disproportionate to a decline in pulmonary physiology, suggests a recent study, noting that this change in DPA may be used as a prognostic tool to assess disease progression.



