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COVID-19 pandemic has shortened life expectancy in 2020: study
Life expectancy has decreased during the COVID-19 pandemic, with more than 28 million excess life years of life lost in 2020 in 31 countries, according to a study, noting a higher rate in men than women.

SG’s COVID-19 lockdown takes toll on older adults’ mental, financial wellbeing
During Singapore’s coronavirus disease 2019 (COVID-19) lockdown, older adults experienced a decrease in depressive symptoms accompanied by growing feelings of loneliness and lower physical activity (PA), according to a recent study.

Novel tenofovir formulation noninferior to disoproxil fumarate in chronic hepatitis B
In the treatment of patients with chronic hepatitis B (CHB), the novel tenofovir amibufenamide (TMF) is as good as tenofovir disoproxil fumarate (TDF) in terms of efficacy but with the advantage of better bone and renal safety, according to the results of a noninferiority trial.

Spike mutations in COVID-19 variants threaten vaccine efficacy
Due to mutations in the virus’ Spike protein, the antibody neutralization activity of convalescent patients with the coronavirus disease 2019 (COVID-19) seems to be attenuated against the B.1.1.7 and B.1.351 strains of SARS-CoV-2, according to a recent Singapore study.

Do mRNA COVID-19 vaccines influence treatment for rheumatic diseases?
In individuals receiving disease-modifying antirheumatic drugs* (DMARDs) for inflammatory rheumatic diseases** (IRD), humoral response remained satisfactory following administration of the second dose of the Pfizer mRNA vaccine against SARS-CoV-2, a study suggests.



