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Long-term semaglutide reduces diabetes risk
In a prespecified secondary analysis of the SELECT trial, long-term treatment with semaglutide allows more patients with prediabetes to regress to normoglycaemia while reducing progression to diabetes in some patients. However, semaglutide does not slow glycaemic progression over time.

CLD status does not influence MACE risk associated with ticagrelor vs clopidogrel
Use of ticagrelor compared with clopidogrel contributes to a similar risk of major adverse cardiovascular events (MACE) and a higher risk of major bleeding in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI), reveals a study.

Prior MI or stroke may predict diuretic use for HTN management
A prespecified secondary analysis of the Diuretic Comparison Project (DCP) shows that when deciding between chlorthalidone (CTD) and hydrochlorothiazide (HCTZ) for the management of hypertension (HTN), a history of myocardial infarction (MI) or stroke may have to be considered.






