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ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

10 Apr 2024

Gartisertib, an oral inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), for patients with advanced solid tumours is well tolerated at lower doses, according to the results of a phase I study. However, unexpected liver toxicity prevents dose escalation and, in turn, limits the drug’s antitumour activity.

ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

10 Apr 2024

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

09 Apr 2024 bởi

Statin therapy appears to result in a modest elevation in blood sugar levels, increasing the likelihood of diabetes development especially among people whose blood sugar levels are already near the diagnostic threshold, according to a meta-analysis.

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

09 Apr 2024

Asthma control better with dupilumab-ICS combo

09 Apr 2024 bởi

Adding the anti-interleukin-4 receptor alpha monoclonal antibody dupilumab to an inhaled corticosteroid (ICS) reduces asthma exacerbations and improves lung function in a post hoc analysis of the LIBERTY ASTHMA QUEST trial.

Asthma control better with dupilumab-ICS combo

09 Apr 2024

2 drugs in 1 pill better than complex regimens for HIV

09 Apr 2024 bởi

The combination of bictegravir and lenacapavir, taken orally once daily, performed better than current complex treatment regimens in the phase II ARTISTRY-1 trial of people with HIV who are virologically suppressed.

2 drugs in 1 pill better than complex regimens for HIV

09 Apr 2024

Novel drug significantly cuts triglyceride levels

08 Apr 2024 bởi

The investigational RNAi therapeutic plozasiran significantly reduced triglyceride levels in individuals with severe hypertriglyceridaemia (SHTG) who were at high risk for pancreatitis, according to the final results of the phase IIb SHASTA-2 trial.

Novel drug significantly cuts triglyceride levels

08 Apr 2024

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

07 Apr 2024

Adding desloratadine to an isotretinoin regimen appears to reduce pruritus in acne, leading to a higher patient satisfaction, as shown in a study.

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

07 Apr 2024

Filgotinib for ulcerative colitis holds up in real world

07 Apr 2024

The oral Janus kinase (JAK) 1 preferential inhibitor filgotinib appears to be safe and effective in the treatment of Asian patients with ulcerative colitis, according to real-world data.

Filgotinib for ulcerative colitis holds up in real world

07 Apr 2024

Testosterone replacement therapy of little help in preventing diabetes in hypogonadal men

06 Apr 2024

Testosterone replacement therapy in men with hypogonadism does not appear to reduce the risk of developing diabetes, according to the results of the TRAVERSE* substudy.

Testosterone replacement therapy of little help in preventing diabetes in hypogonadal men

06 Apr 2024

Meta-analysis: Abbreviated DAPT after PCI may be considered for older adults

06 Apr 2024 bởi

Older adults who have undergone percutaneous coronary intervention (PCI) may do well with a shortened dual antiplatelet therapy (DAPT) duration, which has been shown to reduce the risk of bleeding without increasing the risk of adverse clinical events in a network meta-analysis.

Meta-analysis: Abbreviated DAPT after PCI may be considered for older adults

06 Apr 2024

Benralizumab beneficial to Asians with severe eosinophilic asthma

05 Apr 2024

The efficacy of benralizumab against severe eosinophilic asthma has been confirmed in an Asian population, with results consistent with the global data, as shown in the phase III MIRACLE trial.

Benralizumab beneficial to Asians with severe eosinophilic asthma

05 Apr 2024

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ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

Asthma control better with dupilumab-ICS combo

Asthma control better with dupilumab-ICS combo

2 drugs in 1 pill better than complex regimens for HIV

2 drugs in 1 pill better than complex regimens for HIV

Novel drug significantly cuts triglyceride levels

Novel drug significantly cuts triglyceride levels

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

Filgotinib for ulcerative colitis holds up in real world

Filgotinib for ulcerative colitis holds up in real world

Testosterone replacement therapy of little help in preventing diabetes in hypogonadal men

Testosterone replacement therapy of little help in preventing diabetes in hypogonadal men

Meta-analysis: Abbreviated DAPT after PCI may be considered for older adults

Meta-analysis: Abbreviated DAPT after PCI may be considered for older adults

Benralizumab beneficial to Asians with severe eosinophilic asthma

Benralizumab beneficial to Asians with severe eosinophilic asthma