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Odevixibat reduces bile acids, improves sleep, pruritus in Alagille syndrome

16 Jun 2023 bởi

Patients with Alagille syndrome (AS) may benefit from treatment with odevixibat, with the phase III ASSERT study showing that its use results in rapid, sustained, and highly significant improvements in pruritus, sleep quality, as well as decreases in bile acids (BAs). Odevixibat is also well tolerated.

Odevixibat reduces bile acids, improves sleep, pruritus in Alagille syndrome

16 Jun 2023

Thiazide plus potassium-sparing diuretics outdoes monotherapy in hypertension

16 Jun 2023

Use of thiazides with potassium-sparing (PS) diuretics results in greater blood pressure (BP)-lowering efficacy, as well as reduces hypokalaemia and hyperglycaemia, compared with thiazides alone, reports a recent study.

Thiazide plus potassium-sparing diuretics outdoes monotherapy in hypertension

16 Jun 2023

Ribociclib plus endocrine therapy: A win for early breast cancer?

16 Jun 2023 bởi

In the second interim efficacy analysis of the phase III NATALEE trial, a combination regimen comprising the CDK4/6 inhibitor ribociclib and endocrine therapy (ET) demonstrated favourable signals for the adjuvant treatment of stage II/III hormone receptor-positive, HER2-negative (HR+, HER2–) early breast cancer.

Ribociclib plus endocrine therapy: A win for early breast cancer?

16 Jun 2023

Original New Drug Application Approvals by US FDA (01-15 June 2023)

16 Jun 2023

New drug applications approved by US FDA as of 01-15 June 2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01-15 June 2023)

16 Jun 2023

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

Antifibrotic treatment appears to put brakes on the decline of lung function, as evidenced by forced vital capacity (FVC) measurements, in patients with interstitial lung disease (ILD) related to connective tissue disease (CTD) or rheumatoid arthritis (RA), according to a study.

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

Telitacicept tied to higher SRI-4 response in SLE patients

16 Jun 2023 bởi

Among patients with active systemic lupus erythematosus (SLE), treatment with telitacicept significantly increased SLE Responder Index 4 (SRI-4) response rate at week 52 compared with placebo, according to a study presented at EULAR 2023.

Telitacicept tied to higher SRI-4 response in SLE patients

16 Jun 2023

Teduglutide effective in children with SBS, but still costly

15 Jun 2023 bởi

Use of teduglutide is effective against short bowel syndrome (SBS) in paediatric patients, although some children need a longer duration of treatment to achieve enteral autonomy, according to a Spain study presented at ESPGHAN 2023. Predictive factors of response to treatment have not been identified.

Teduglutide effective in children with SBS, but still costly

15 Jun 2023

Pain mechanisms tied to disease activity in DMARD-treated RA

15 Jun 2023

A recent study has shown the importance of identifying and treating aberrant peripheral and central pain regulation in patients with rheumatoid arthritis (RA) who are either initiating or switching to disease-modifying antirheumatic drug (DMARD) treatment.

Pain mechanisms tied to disease activity in DMARD-treated RA

15 Jun 2023

Dupilumab shows benefit in young children with EoE

15 Jun 2023 bởi

Treatment with dupilumab significantly improves histologic and endoscopic measures of eosinophilic esophagitis (EoE) in young children aged 1–11 years, according to the phase III EoE KIDS trial presented at ESPGHAN 2023.

Dupilumab shows benefit in young children with EoE

15 Jun 2023

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

14 Jun 2023

Treatment with sacubitril/valsartan appears to be better than valsartan alone in reversing ventricular remodeling in perimenopausal hypertensive women, suggests a study.

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

14 Jun 2023

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Odevixibat reduces bile acids, improves sleep, pruritus in Alagille syndrome

Odevixibat reduces bile acids, improves sleep, pruritus in Alagille syndrome

Thiazide plus potassium-sparing diuretics outdoes monotherapy in hypertension

Thiazide plus potassium-sparing diuretics outdoes monotherapy in hypertension

Ribociclib plus endocrine therapy: A win for early breast cancer?

Ribociclib plus endocrine therapy: A win for early breast cancer?

Original New Drug Application Approvals by US FDA (01-15 June 2023)

Original New Drug Application Approvals by US FDA (01-15 June 2023)

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

Telitacicept tied to higher SRI-4 response in SLE patients

Telitacicept tied to higher SRI-4 response in SLE patients

Teduglutide effective in children with SBS, but still costly

Teduglutide effective in children with SBS, but still costly

Pain mechanisms tied to disease activity in DMARD-treated RA

Pain mechanisms tied to disease activity in DMARD-treated RA

Dupilumab shows benefit in young children with EoE

Dupilumab shows benefit in young children with EoE

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension