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S1PR1 agonist a promising treatment for rheumatoid arthritis

The selective agonist of sphingosine-1-phosphate receptor-1 (S1PR1), proximod, appears to be well tolerated and helps reduce blood lymphocyte count in patients with rheumatoid arthritis (RA), according to a phase I study.

S1PR1 agonist a promising treatment for rheumatoid arthritis

7 days of antibiotics as effective as 14 days for bloodstream infections

02 Dec 2024 bởi

In the noninferiority BALANCE* trial, 7 days of antibiotic use is as effective as 14 days for treating bloodstream infections (BSIs) in hospitalized patients, drawing renewed interest from clinicians attending IDWeek 2024.

7 days of antibiotics as effective as 14 days for bloodstream infections

Statins confer protection against portal hypertension, mortality in cirrhosis

01 Dec 2024 bởi

Statins appear to be beneficial to patients with cirrhosis, being associated with reduced risks of portal hypertension and its complications as well as death, according to a study.

Statins confer protection against portal hypertension, mortality in cirrhosis

Palbociclib vs abemaciclib: How to choose the right treatment for breast cancer patients

A study suggests that in choosing CDK4/6 inhibitors (palbociclib and abemaciclib) for patients with hormone receptor-positive, HER2-negative metastatic/recurrent breast cancer, considerations must be made based on the tolerability and manageability of adverse events (AEs).

Palbociclib vs abemaciclib: How to choose the right treatment for breast cancer patients

01 Dec 2024

Serum urate may be safely lowered in gout patients with impaired kidney function

Achieving target serum urate levels with urate-lowering therapy (ULT) does not appear to worsen kidney function in patients with gout and chronic kidney disease (CKD), as shown in a study.

Serum urate may be safely lowered in gout patients with impaired kidney function

Severe maternal morbidity during first birth reduces chances of future births

First-time mothers who sustain life-threatening events during pregnancy, delivery, and up to 42 days postpartum are less likely to have more children, as suggested in a large retrospective study.

Severe maternal morbidity during first birth reduces chances of future births

Wildfire exposure spell dementia risk

30 Nov 2024 bởi

Exposure to fine particulate matter (PM2.5) from wildfire smoke carries a heightened risk of dementia, as shown in a study.

Wildfire exposure spell dementia risk

Urea on par with tolvaptan for hyponatremia

Urea is as effective as tolvaptan in the treatment of hyponatremia, with a lower incidence of overcorrection, as shown in a study.

Urea on par with tolvaptan for hyponatremia

30 Nov 2024

More frequent testing does not translate to increased survival in colorectal cancer

Increasing the frequency of CT scan and carcinoembryonic antigen (CEA) testing does not appear to produce a significant reduction in 10-year overall mortality or colorectal cancer–specific mortality for patients with stage II or III colorectal cancer (CRC), according to a study.

More frequent testing does not translate to increased survival in colorectal cancer