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Thoracoscopic esophagectomy (TE) has demonstrated its noninferiority to open transthoracic esophagectomy (OE) for patients with thoracic esophageal cancer in a study presented at ASCO GI 2024.

Thoracoscopic esophagectomy better than open surgery in esophageal cancer

Serum klotho reduction ups death risk in persons with vitamin D deficiency

A decreasing klotho, a biomarker of vitamin D activation and metabolism, plays a key role in the association between 25-hydroxyvitamin D (25[OH]D) and mortality, reveals a study. This finding suggests that a disruption in vitamin D metabolism leads to an increased risk of death.

Serum klotho reduction ups death risk in persons with vitamin D deficiency

Maternal transplacental transfer of nipocalimab negligible in foetuses, neonates

In the phase II UNITY study, foetuses and neonates whose mums were receiving nipocalimab for early-onset (≤24 weeks gestational age [GA]) severe haemolytic disease of the foetus and newborn (EOS-HDFN) had minimal exposure to the drug.

Maternal transplacental transfer of nipocalimab negligible in foetuses, neonates

Low-dose oral midazolam not linked to improved patient satisfaction after surgery

Premedication with low-dose oral midazolam in older patients undergoing a surgical procedure falls short of improving perioperative patient satisfaction, according to a study.

Low-dose oral midazolam not linked to improved patient satisfaction after surgery

Dementia risk threefold higher in the first year after a stroke

Stroke survivors were more likely to develop dementia within the first year following their stroke than the general population and people with acute myocardial infarction (MI), according to a study presented at ISC 2024.

Dementia risk threefold higher in the first year after a stroke

Abiraterone vs docetaxel in Asian mHSPC patients: What’s the difference?

A real-world analysis of 574 Asian patients with metastatic hormone-sensitive prostate cancer (mHSPC) demonstrated a significantly longer progression-free survival (PFS) and similar overall survival (OS) with abiraterone plus androgen deprivation therapy (ADT) vs docetaxel plus ADT.

Abiraterone vs docetaxel in Asian mHSPC patients: What’s the difference?

Acetylcholinesterase inhibitors may have potential protective effect against AMD

In the treatment of individuals with Alzheimer’s disease, acetylcholinesterase inhibitors (AChEIs) appear to confer a small reduction in the risk of age-related macular degeneration (AMD), as shown in a study.

Acetylcholinesterase inhibitors may have potential protective effect against AMD

Stroke risk high among head and neck cancer survivors in SG

22 Feb 2024 bởi

Survivors of head and neck cancer (HNC) in Singapore have a more than twofold increased risk of stroke, regardless of age, cancer subsites, and treatment modalities, among others, according to a study.

Stroke risk high among head and neck cancer survivors in SG

TRT boosts sexual function, eases symptoms in men with hypogonadism

Testosterone replacement therapy (TRT) can help increase sexual activity, improve hypogonadal symptoms, and boost sexual desire among middle-aged and older men with hypogonadism and low libido, reports a study. However, TRT does not improve erectile function.

TRT boosts sexual function, eases symptoms in men with hypogonadism

22 Feb 2024

Immunogenicity does not affect pharmacokinetics, efficacy of tirzepatide

22 Feb 2024 bởi

Treatment-emergent (TE) antidrug antibodies (ADA) do not show any influence on the pharmacokinetics or efficacy of tirzepatide (TZP), as shown in a study. Most of the hypersensitivity or injection site reactions in patients with TE ADA are either mild or moderate in severity.

Immunogenicity does not affect pharmacokinetics, efficacy of tirzepatide