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Add-on bevacizumab ups hypertension risk in CRC patients
The addition of bevacizumab (BVZ) to the standard regimen for the treatment of advanced colorectal cancer (CRC) appears to increase the risk of cardiovascular events, suggest the results of a meta-analysis presented at the recent ASCO Gastrointestinal Cancers Symposium (ASCO GI 2023).
Tislelizumab–chemotherapy combo poised as new first-line option for advanced gastric cancer
Adding the anti-PD-1 monoclonal antibody tislelizumab to chemotherapy in the first-line treatment of PD-1-positive advanced gastric or gastroesophageal junction adenocarcinoma appears to produce significant and clinically meaningful improvements in survival outcomes while having an acceptable safety profile, according to interim data from the phase III RATIONALE 305 trial.
Saroglitazar may lower cardiovascular risk in NAFLD
Treatment with the dual PPAR α/γ agonist saroglitazar helps improve the serum atherogenic lipoprotein profile in patients with nonalcoholic fatty liver disease (NAFLD), regardless of comorbid conditions and statin use, as shown in a study.
Preop chemotherapy confers survival advantage in colorectal cancer with liver metastasis
Giving chemotherapy to patients with synchronous and unresectable liver metastases from colorectal cancer before undergoing primary tumour resection helps boost survival outcomes, according to a phase III trial presented at this year’s ASCO Gastrointestinal Cancer Symposium (ASCO GI).
Indomethacin plus somatostatin helps avert pancreatitis in ERCP patients
The addition of somatostatin to rectal indomethacin is safe and effective in the prevention of postendoscopic retrograde cholangiopancreatography (post-ERCP) hypermylasemia and pancreatitis (PEP) in high-risk patients, reports a study.