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Administering serial ketamine infusions does not show a clear advantage over serial midazolam infusions for reducing depressive symptoms in patients receiving standard inpatient psychiatric care, according to the KARMA-Dep 2 trial.

New drug applications approved by US FDA as of 16-30 September 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Distress about low sexual function correlates positively with the severity of sexual pain and negatively with sexual satisfaction among women, reports a study.

Impulsivity appears to be associated with violent sexual behaviour (VSB) in individuals with compulsive sexual behaviour (CSB) who suffered childhood abuse, reveals a study.

The real-world use of esketamine nasal spray is safe and has a safety profile consistent with that established in clinical studies and current product labeling, reports a US study. No new safety signals have been noted.

Both the Patient Healthcare Questionnaire (PHQ) and the Hospital Anxiety and Depression Scale (HADS) are useful for identifying stroke survivors with depression in Singaporean inpatient rehabilitation care settings, as shown in a study.

A slow-tempo music intervention falls short of reducing the duration and severity of delirium in older patients on mechanical ventilation, according to a study.