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Can mouthwash cut COVID-19 salivary viral load?
In COVID-19 patients who had mild or no symptoms, the use of 0.05% cetylpyridinium chloride (CPC) and 0.01% on-demand aqueous chlorine dioxide (ACD) mouthwashes did not lead to a reduction in SARS-CoV-2 salivary viral load.

Nirmatrelvir-ritonavir bests molnupiravir in COVID-19 patients with advanced kidney disease
In a retrospective observational study, nirmatrelvir-ritonavir trumps molnupiravir in reducing the risk of all-cause mortality at 90 days and hospitalization in COVID-19 patients with advanced kidney disease (chronic kidney disease [CKD] stage 4, ie, eGFR <30 mL/min/1.73 m2).

Glecaprevir/pibrentasvir shows favourable efficacy signals for paediatric HCV
Findings from the ongoing POLAC project demonstrate that treatment with the pangenotypic regimen comprising glecaprevir/pibrentasvir (GLE/PIB) for 8 weeks is highly effective against chronic hepatitis C virus (HCV) infection in children and adolescents. This regimen also showed a good safety profile.





