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Adolescents and adults with severe uncontrolled asthma while on inhaled corticosteroids (ICS) had greater responses to the human monoclonal antibody tezepelumab than placebo, according to prespecified exploratory results of the phase III NAVIGATOR trial.

27 Jun 2022

Stinging, burning sensation after DED medication use a major concern to patients

Patients with dry eye disease (DED) can achieve optimal symptom alleviation with available medications, but getting patients to take their medications remains a challenge due to side effects. Taking the burn or sting out of medications might help, according to a Singapore study.

Vonoprazan superior to PPI for heartburn resolution in erosive esophagitis patients

Vonoprazan 20 mg once daily (QD) appears as effective as proton pump inhibitors (PPIs) on day 1 and equally or more effective on day 7 in the treatment of heartburn in adults with erosive esophagitis, results of a network meta-analysis have shown.

Pharmacist intervention confers benefits on cardiovascular outcomes

Pharmacist interventions help improve cardiovascular disease management, including risk factor control, better medication adherence, and reduction in morbidity and mortality, a study has found.

27 Jun 2022

Infliximab, adalimumab biosimilars effective, safe in paediatric IBD

The use of biosimilars of infliximab (IFX) and adalimumab (ADA) is both safe and effective in children with inflammatory bowel disease (IBD), inducing high rates of failure-free survival with a low incidence of adverse events, according to a study presented at the 2022 Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN 2022).

27 Jun 2022

Regular statin use offers protection against diabetes in acute pancreatitis patients

Regular statin users appear to be at lower risk of developing diabetes mellitus following an episode of acute pancreatitis, as shown in a study.

Glargine, degludec improve glycaemic control in patients switching from first-gen insulin

Among type 2 diabetes (T2D) patients on first-generation basal insulins (1BIs), a switch to either glargine or degludec in the real-world setting leads to marked improvements in glucose control without increasing the risk of hypoglycaemic events and weight gain, according to a study. Furthermore, the benefits seem to be comparable between the two second-generation basal insulins (2BIs).

Revacept beneficial to patients with symptomatic ICA stenosis

Patients with symptomatic internal carotid artery (ICA) stenosis may fare well with revacept, a competitive antagonist of glycoprotein VI, as the drug helps reduce the incidence of stroke or death, transient ischaemic attack, and bleeding complications, among others, according to a study.

$Add-on baclofen eases reflux in certain PPI-refractory GERD patients$

Add-on baclofen eases reflux in certain PPI-refractory GERD patients

In patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD), add-on treatment with baclofen improves several reflux parameters, but only among those who are positive for symptom association probability, a study has found.