Tin tức & Cập nhật

The incidence of leaflet thrombosis in patients without an indication for long-term anticoagulation after transcatheter aortic-valve replacement (TAVR) appears to be lower with edoxaban than with dual antiplatelet therapy (DAPT) although not significantly so, according to the results of the open-label ADAPT-TAVR trial.

Neoadjuvant treatment with nivolumab appears to induce a major pathologic response in selected patients with resectable gastric cancer, in addition to having an acceptable safety profile, according to the results of a phase I trial.

Actively treating even mild hypertension to a target blood pressure (BP) of <140/90 mm Hg in pregnant women significantly lowers the risk of adverse pregnancy outcomes without apparent harm to the foetus compared with a strategy of reserving treatment to only when hypertension becomes severe (≥160/105 mm Hg), according to the CHAP* study presented at ACC 2022.

Use of the dopamine 3 receptor agonist pramipexole (PPX) as adjuvant therapy appears to facilitate the reduction of patient exposure to opioids and its associated risks, according to a study.

The use of mitapivat increased haemoglobin (Hb) levels in patients with pyruvate kinase deficiency (PKD) who did not receive any regular blood transfusions, according to the ACTIVATE* study.

Taking P2B001, a novel polypill comprising fixed-dose combination of 0.6 mg pramipexole (PPX) and 0.75 mg of rasagiline (RAS), was better than taking either drug component alone for symptomatic control of Parkinson’s disease, according to results of a late-breaking phase III study presented at AAN 2022.