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Zonulin levels appear to substantially increase in the months leading up to a diagnosis of coeliac disease, as reported in a study. Additionally, exposure to a greater number of antibiotic courses contribute to an increase in zonulin levels in individuals with coeliac disease, highlighting a potential role for the marker in preclinical screening.

New drug applications approved by US FDA as of 16-30 November  2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

The risk of colectomy in paediatric onset ulcerative colitis (UC) has significantly decreased at the population level along with an increase in the use of immunosuppressants and antitumour necrosis factor (anti-TNF), reports a study.

A propensity-matched study has found no significant difference in the effectiveness of ciprofloxacin, metronidazole, or combination therapy in the real-world setting for an initial episode of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis.

A wireless, capsule-like ingestible device can measure multiple vital signs from within the gastrointestinal tract, having the potential to diagnose sleep-related respiratory disorders and capture life-threatening events such as apnoea or opioid overdose, according to a study.

A novel microbiome technology developed by researchers at the Chinese University of Hong Kong (CUHK) enhances faecal microbiota transplantation (FMT) success rate to >90 percent in patients with recurrent Clostridioides difficile infection (CDI). FMT with the novel technology will become available in public hospitals in Hong Kong.