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New drug applications approved by US FDA as of 16-31 July 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
In patients with cirrhosis and upper gastrointestinal (GI) bleeds, mortality outcome does not differ between shorter and longer antibiotic prophylaxis durations, according to a systematic review and Bayesian meta-analysis.
Higher esophageal anxiety, use of adaptive behaviours, and hypervigilance are common among patients with active eosinophilic esophagitis (EoE), representing clinical markers of histological disease activity (HDA), a study has found.
Greater severity in metabolic dysfunction-associated steatotic liver disease (MASLD) may impair cognitive function and health-related quality of life (HRQoL) in patients with overweight or obesity, suggests a study.
High adiposity levels are associated with the risk of colorectal cancer (CRC), suggest the results of a systematic review. However, standardization is necessary to improve understanding of the link between CRC and adiposity to enable comparisons across papers.
Glycaemic outcomes following sleeve gastrectomy (SG) vary by race and ethnicity, with non-Hispanic Black (NHB) participants showing less favourable outcomes, reports a study.
Treatment with vedolizumab exhibits equivalent rates of response and mucosal healing but higher odds of drug persistence and achieving clinical remission compared with adalimumab in biologic-naïve patients with Crohn’s disease (CD), reports a study in a real-world setting.
Keeping a healthy lifestyle such as having a balanced diet, regular exercise, and quality sleep may provide survival benefits to patients with cirrhosis, suggests a study.
Treatment with budesonide shows better clinical remission rates and fewer adverse events (AEs) than mesalamine in patients with microscopic colitis (MC), reveals a study.
Primary sclerosing cholangitis (PSC) poses an increased risk of colorectal cancer (CRC), even in the absence of concomitant inflammatory bowel disease (IBD), according to a retrospective study.
