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High piperacillin-tazobactam (PTZ) dosing does not lead to increased acute nephrotoxicity, thrombocytopenia, 14-day all-cause mortality, or intensive care unit (ICU) length of stay (LOS), suggests a recent study.

Is it safe to use high-dose PTZ in critically ill patients with obesity?

Bariatric surgery more effective, affordable than GLP-1RAs for severe obesity

For individuals with class II and III obesity, metabolic bariatric surgery appears to result in durable weight loss at lower ongoing costs when compared with glucagon-like peptide-1 receptor agonists (GLP-1RAs), according to a study.

Bariatric surgery more effective, affordable than GLP-1RAs for severe obesity

Energy-reduced MedDiet plus physical activity prevents T2D in persons with obesity

An intensive intervention with energy-reduced Mediterranean diet (MedDiet) combined with physical activity demonstrates greater efficacy than an ad libitum MedDiet only in lowering the incidence of diabetes in persons with overweight or obesity and metabolic syndrome, according to a study.

Energy-reduced MedDiet plus physical activity prevents T2D in persons with obesity

Pomegranate supplementation mitigates several cardiometabolic risk factors

Pomegranate supplementation helps improve certain risk factors for cardiometabolic syndrome, including body weight, BMI, blood pressure, fasting blood glucose, total cholesterol, and high-density lipoprotein (HDL), according to a systematic review and meta-analysis.

Pomegranate supplementation mitigates several cardiometabolic risk factors

Original New Drug Application Approvals by US FDA (16-31 August 2025)

New drug applications approved by US FDA as of 16-31 August 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-31 August 2025)

Mediterranean–DASH diet improves health outcomes in T2D, hypertension

Adherence to the Mediterranean–Dietary Approaches to Stop Hypertension (DASH) diet leads to improvements in anthropometric, laboratory parameters, and blood pressure (BP) in patients with type 2 diabetes (T2D) and hypertension, reports a study. This intervention also improves satiety levels throughout the day.

Mediterranean–DASH diet improves health outcomes in T2D, hypertension

Semaglutide works well for Asians with obesity

Once-weekly treatment with semaglutide is safe and induces weight loss in Asians with obesity, according to the phase III STEP 11 trial.

Semaglutide works well for Asians with obesity