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A significant increase in blood pressure (BP) appears predictive of therapeutic response to vascular endothelial growth factor (VEGF) inhibitors but does not limit treatment duration even in patients with severe elevations, suggests a study.

Significant BP elevation predicts response to VEGF inhibitors

Plasma bile acid levels linked to cardiometabolic risk factors in young adults

08 Mar 2022 bởi

Plasma levels of bile acids (BA) appear to be dependent on sex and correlate with cardiometabolic and inflammatory risk factors in young and relatively healthy adults, according to a study.

Plasma bile acid levels linked to cardiometabolic risk factors in young adults

Severe hypoglycaemia raises risk of heart failure in adults with T2D

Severe hypoglycaemia may contribute to a higher risk of incident heart failure (HF) among adults with type 2 diabetes (T2D), reports a study.

Severe hypoglycaemia raises risk of heart failure in adults with T2D

08 Mar 2022

Interactive text messaging helps control blood pressure in ED

An intervention that involves informational and reminder text messages, among others, is a feasible approach for managing elevated blood pressure (BP) in the emergency department (ED) setting, as reported in a study.

Interactive text messaging helps control blood pressure in ED

ICH, high NIHSS score predict mortality in stroke after reperfusion

Some acute ischaemic stroke patients treated with mechanical thrombectomy remain at risk of death despite successful reperfusion, a study reports. Among these patients, symptomatic intracranial haemorrhage (ICH) and high post-thrombectomy National Institutes of Health Stroke Scale (NIHSS) score strongly predict 90-day mortality.

ICH, high NIHSS score predict mortality in stroke after reperfusion

Hs-cTnI less accurate at diagnosing MI in patients with prior CABG

05 Mar 2022

High-sensitivity cardiac troponin I (hs-cTnI) loses diagnostic accuracy for myocardial infarction (MI) in patients who had undergone prior coronary artery bypass grafting (CABG), though it remains highly sensitive and specific, a new study has found.

Hs-cTnI less accurate at diagnosing MI in patients with prior CABG

05 Mar 2022

T2D: Risk of CV and all-cause mortality lower with SGLT2 vs DPP-4 inhibitors

05 Mar 2022 bởi

A real-world propensity score-matched study in Hong Kong finds that, compared with use of dipeptidyl peptidase-4 (DPP-4) inhibitors, use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in type 2 diabetes (T2D) patients is associated with lower risk of incident atrial fibrillation (AF), stroke/transient ischaemic attack (TIA), and cardiovascular (CV) and all-cause mortality.

T2D: Risk of CV and all-cause mortality lower with SGLT2 vs DPP-4 inhibitors

05 Mar 2022

Original New Drug Application Approvals by US FDA (16 - 28 February 2022)

New drug applications approved by US FDA as of 16-28 February 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16 - 28 February 2022)

Add-on electrostimulation of no benefit to paediatric cystic fibrosis patients

A resistance exercise-training program is enough to yield gains in muscle strength and functional capacity in paediatric cystic fibrosis (CF) patients with mild-to-moderate pulmonary impairment, a study has found. Meanwhile, the addition of neuromuscular electrical stimulation (NMES) does not appear to provide extra benefit.

Add-on electrostimulation of no benefit to paediatric cystic fibrosis patients