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Viral suppression is maintained through 48 weeks in adults with HIV-1 harbouring drug resistance mutations, who switched to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) fixed-dose combination pill from a boosted protease inhibitor (bPI) therapy, according to recent data from the phase IV open-label PIBIK trial.

PIBIK: Switching to B/F/TAF maintains HIV suppression through 48 weeks

Some signal of benefit found for liberal transfusion strategy for anaemic heart attack patients

Adopting a liberal blood transfusion strategy in patients with acute myocardial infarction (AMI) and anaemia does not appear to do much in terms of reducing the risk of AMI recurrence or death compared with a restrictive transfusion strategy, although there appears to be a hint of benefit, as shown in the results of the phase III MINT trial.

Some signal of benefit found for liberal transfusion strategy for anaemic heart attack patients

HRV/EV infections affect the respiratory system, yield low mortality rates

The respiratory system is the main target of human rhinovirus/enterovirus (HRV/EV) infections, which show a clinical course with low mortality rates, reveals a study.

HRV/EV infections affect the respiratory system, yield low mortality rates

Givosiran delivers safe, sustained improvements in acute hepatic porphyria

Long-term monthly treatment with givosiran has good tolerability and offers continuous improvements to patients with acute hepatic porphyria (AHP), results of the phase III ENVISION trial have shown.

Givosiran delivers safe, sustained improvements in acute hepatic porphyria

Omega 6 fatty acids do not influence AF development

Biomarkers of omega 6 (n‒6) fatty acids, including linoleic acid (LA) and arachidonic acid (AA), show no significant relationship with incident atrial fibrillation (AF), a study has found.

Omega 6 fatty acids do not influence AF development

Convalescent plasma cuts death in mechanically ventilated patients with COVID-19-induced ARDS

In the CONFIDENT trial, convalescent plasma (CCP) conferred a mortality benefit for patients with COVID-19-induced acute respiratory distress syndrome (ARDS) who were on invasive mechanical ventilation (IMV).

Convalescent plasma cuts death in mechanically ventilated patients with COVID-19-induced ARDS

28 Nov 2023

Intracranial atherosclerosis disease linked to cognitive impairment, dementia

Individuals with intracranial atherosclerosis disease (ICAD) have a heightened risk of cognitive impairment and dementia, according to the results of a systematic review and meta-analysis.

Intracranial atherosclerosis disease linked to cognitive impairment, dementia

28 Nov 2023

Biologic dose optimization not needed in UC patients with early nonresponse, high drug clearance

For patients with ulcerative colitis who are receiving vedolizumab, dose optimization may not be required in the presence of early nonresponse to treatment as well as high drug clearance, according to data from the phase IV ENTERPRET study.

Biologic dose optimization not needed in UC patients with early nonresponse, high drug clearance

Self-monitoring improves postpartum BP control in women with hypertensive pregnancy

27 Nov 2023 bởi

Empowering mums to self-monitor their blood pressure (BP) with a physician-guided titration of antihypertensive medications helps lower postpartum BP level after a pregnancy complicated by hypertension, as shown in the POP-HT trial.

Self-monitoring improves postpartum BP control in women with hypertensive pregnancy

27 Nov 2023

Do children with HRV/EV fare better than those with other respiratory viruses?

Children who test positive for human rhinovirus/enterovirus (HRV/EV) require close monitoring by clinicians, given possible clinical outcomes that are either similar or worse than known highly pathogenic viruses, suggests a recent study.

Do children with HRV/EV fare better than those with other respiratory viruses?