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Conventional interventions including wound drains, ureteral stents and stapled skin closures bypass may no longer be needed for uncomplicated renal transplants, suggests a Singapore study.

Ureteric stents, drains, skin staples not necessary for uncomplicated renal transplants

Prenatal antidepressant exposure does not appear to increase autism risk

Both psychiatric control and discordant-sibling designs do not corroborate the association of exposure to prenatal antidepressants with autism, results of a meta-analysis have shown. Moreover, discordant-sibling designs effectively address surveillance bias in pharmacovigilance reports derived from national registries and other large databases.

Prenatal antidepressant exposure does not appear to increase autism risk

Zoledronic acid fails to ZAP pain, structural progression in knee OA

Annual infusions of zoledronic acid did not significantly cut pain and cartilage volume loss in patients with symptomatic knee osteoarthritis (OA) and bone marrow lesions, the ZAP2* trial has shown.

Zoledronic acid fails to ZAP pain, structural progression in knee OA

Traditional Chinese medicine may hold benefit for kids with ADHD

Traditional Chinese Medication (TCM) may prove to be a valuable adjunct therapy for attention-deficit/hyperactivity disorder (ADHD) in children, according to a recent Singapore study.

Traditional Chinese medicine may hold benefit for kids with ADHD

JAK inhibitors for immune-mediated diseases may increase herpes zoster risk

The use of Janus kinase (JAK) inhibitors for the treatment of inflammatory bowel diseases (IBDs) and other immune-mediated diseases may increase the risk of herpes zoster infection, reports a recent meta-analysis.

JAK inhibitors for immune-mediated diseases may increase herpes zoster risk

Proinflammatory foods may trigger Crohn’s disease

Dietary patterns with high inflammatory potential carry an increased risk of Crohn’s disease (CD) but not ulcerative colitis (UC), according to data from three large prospective studies.

Proinflammatory foods may trigger Crohn’s disease

SSRIs, SNRIs exposure in utero predisposes children to developmental vulnerability

Children of mothers with a mood or anxiety disorder who used selective serotonin reuptake inhibitor (SSRI) or selective serotonin norepinephrine inhibitor (SNRI) during pregnancy are at high risk of developmental vulnerability as well as of language and cognitive difficulties, a study reports.

SSRIs, SNRIs exposure in utero predisposes children to developmental vulnerability

Daily alcohol consumption amplifies diabetes risk

In Japanese patients, drinking alcohol daily may impair insulin secretion and increase the risk of diabetes, a recent study has found.

Daily alcohol consumption amplifies diabetes risk

Olaparib-bevacizumab PFS benefit in ovarian cancer greatest following upfront surgery

20 May 2020 bởi

The combination of olaparib and bevacizumab as maintenance therapy for advanced ovarian cancer appears to confer the greatest progression-free survival (PFS) benefit in women without residual macroscopic disease following upfront cytoreductive surgery, according to an analysis of the phase III PAOLA-1* trial.

Olaparib-bevacizumab PFS benefit in ovarian cancer greatest following upfront surgery

End-of-treatment HBsAg 40 IU/mL an optimal cutoff value for predicting HBV relapse

An end-of-treatment (EOT) HBsAg level 40 IU/mL appears to be a useful cutoff value for predicting hepatitis B virus (HBV) infection relapse following cessation of either entecavir or tenofovir disoproxil fumarate (TDF) treatment, as shown in a study. Specifically, low levels of EOT HBsAg and baseline HBV DNA or HBcrAg translate to reduced odds of having relapse.

End-of-treatment HBsAg 40 IU/mL an optimal cutoff value for predicting HBV relapse