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Neoadjuvant chemoradiation tied to better disease control of soft tissue sarcoma

Management of high-risk soft tissue sarcoma (STS) with neoadjuvant chemoradiation (NA-CRT) shows favourable disease control, reports a new study.

Neoadjuvant chemoradiation tied to better disease control of soft tissue sarcoma

Fixed-duration ibrutinib/venetoclax combo feasible in first-line CLL/SLL treatment

13 Jan 2021 bởi

Patients with chronic lymphocytic leukaemia (CLL)/small lymphocytic lymphoma (SLL) who achieve undetectable minimal residual disease (uMRD) in peripheral blood (PB) and bone marrow (BM) after 12 cycles of first-line treatment with ibrutinib plus venetoclax have similar 1-year disease-free survival (DFS) rates regardless of whether ibrutinib is continued or not, results of the phase II CAPTIVATE study have shown.

Fixed-duration ibrutinib/venetoclax combo feasible in first-line CLL/SLL treatment

Abemaciclib + fulvestrant survival benefit extends to Asians with HR+, HER- ABC

12 Jan 2021 bởi

Adding the CDK4/6 inhibitor abemaciclib to an endocrine therapy of fulvestrant extends overall survival (OS) compared with fulvestrant alone in East Asian patients with hormone receptor-positive (HR+), HER2-negative advanced breast cancer (ABC) who have progressed on prior endocrine therapy, consistent with results from the overall population, updated analysis of the global, phase III MONARCH 2 study has shown.

Abemaciclib + fulvestrant survival benefit extends to Asians with HR+, HER- ABC

Ablative radiotherapy improves survival in patients with second NSCLC

Ablative radiotherapy for new primaries leads to improved overall survival (OS) compared with initial lung cancer stereotactic body radiation therapy (SBRT) in inoperable patients, a recent study has shown.

Ablative radiotherapy improves survival in patients with second NSCLC

UACR a reliable alternative to 24hUP

The urine albumin-to-creatinine ratio (uACR) is an easy and reliable method of ruling out proteinuria >500 mg per day among patients with systemic light chain (AL) amyloidosis, performing relatively well against the 24-hour urine protein collection (24hUP) gold standard, a recent study has found.

UACR a reliable alternative to 24hUP

Flu risk in cancer survivors may hint at severe COVID-19 risk

11 Jan 2021 bởi

A study from England suggests that cancer survivors, particularly haematological cancer survivors, may have a long-term risk of hospitalization or death from influenza compared with individuals with no history of cancer. The study authors believe these findings may help identify cancer survivors at risk for severe COVID-19 outcomes.

Flu risk in cancer survivors may hint at severe COVID-19 risk

Combined PARP, ATR Inhibitors potent against prostate cancer with ATM loss

11 Jan 2021 bởi

A fraction of patients with aggressive prostate cancer have ATM-deficient disease, and this subgroup appears to be most sensitive to the combination of oral drugs targeting PARP* and ATR**, according to a study.

Combined PARP, ATR Inhibitors potent against prostate cancer with ATM loss

Chemoradiation tied to greater tumour regression than chemotherapy in oesophageal cancer

Neoadjuvant chemoradiation (C-RT) for locally advanced oesophageal cancer (LAEC) results in a higher degree of pathologically tumour regression, a study has shown. Outcomes are better among patients with major tumour regression than those with minimal to poor response.

Chemoradiation tied to greater tumour regression than chemotherapy in oesophageal cancer

Which lymph node staging system best predicts prognosis in gastric carcinoma?

The three lymph node (LN) staging systems assessed in a recent study—the eighth TNM staging system, lymph node ratio (LNR, ratio between positive and total LN), and a new anatomic-based classification (Choi classification)—show comparable prognostic performance, but LNR-based classification better stratifies patients with resected gastric carcinoma (GC).

Which lymph node staging system best predicts prognosis in gastric carcinoma?